Journal Article

PUBDB-2019-00829

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reductive power of the archaea right-handed coiled coil nanotube (RHCC-NT) and incorporation of mercury clusters inside protein cages

McDougall, M. ; McEleney, K. ; Francisco, O. ; Trieu, B. ; Ogbomo, E. K. ; Tomy, G. ; Stetefeld, J. (Corresponding author)

2018
Elsevier San Diego, Calif.

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Please use a persistent id in citations: doi:10.1016/j.jsb.2018.05.013  doi:10.3204/PUBDB-2019-00829

Abstract: Coiled coils are well described as powerful oligomerization motifs and exhibit a large diversity of functions, including gene regulation, cell division, membrane fusion and drug extrusion. The archaea S-layer originated right-handed coiled coil –RHCC-NT- is characterized by extreme stability and is free of cysteine and histidine moieties. In the current study, we have followed a multidisciplinary approach to investigate the capacity of RHCC-NT to bind a variety of ionic complex metal ions. At the outside of the RHCC-NT, one mercury ion forms an electrostatic interaction with the S-methyl moiety of the single methionine residue present in each coil. We demonstrate that RHCC-NT is reducing and incorporating metallic mercury in the large-sized interior cavities which are lined up along the tetrameric channel.

Note: © Elsevier Inc.

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Contributing Institute(s):

1. DOOR-User (DOOR)

Research Program(s):

1. 899 - ohne Topic (POF3-899) (POF3-899)

Experiment(s):

1. DORIS Beamline BW7 (DORIS III)

Appears in the scientific report 2018

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