TY  - JOUR
AU  - McDougall, Matthew
AU  - McEleney, Kevin
AU  - Francisco, Olga
AU  - Trieu, Benchmen
AU  - Ogbomo, Efehi Kelly
AU  - Tomy, Gregg
AU  - Stetefeld, Jörg
TI  - Reductive power of the archaea right-handed coiled coil nanotube (RHCC-NT) and incorporation of mercury clusters inside protein cages
JO  - Journal of structural biology
VL  - 203
IS  - 3
SN  - 1047-8477
CY  - San Diego, Calif.
PB  - Elsevier
M1  - PUBDB-2019-00829
SP  - 281 - 287
PY  - 2018
N1  - © Elsevier Inc.
AB  - Coiled coils are well described as powerful oligomerization motifs and exhibit a large diversity of functions, including gene regulation, cell division, membrane fusion and drug extrusion. The archaea S-layer originated right-handed coiled coil –RHCC-NT- is characterized by extreme stability and is free of cysteine and histidine moieties. In the current study, we have followed a multidisciplinary approach to investigate the capacity of RHCC-NT to bind a variety of ionic complex metal ions. At the outside of the RHCC-NT, one mercury ion forms an electrostatic interaction with the S-methyl moiety of the single methionine residue present in each coil. We demonstrate that RHCC-NT is reducing and incorporating metallic mercury in the large-sized interior cavities which are lined up along the tetrameric channel.
LB  - PUB:(DE-HGF)16
C6  - pmid:29879486
UR  - <Go to ISI:>//WOS:000442713100012
DO  - DOI:10.1016/j.jsb.2018.05.013
UR  - https://bib-pubdb1.desy.de/record/418925
ER  -