%0 Journal Article
%A McDougall, Matthew
%A McEleney, Kevin
%A Francisco, Olga
%A Trieu, Benchmen
%A Ogbomo, Efehi Kelly
%A Tomy, Gregg
%A Stetefeld, Jörg
%T Reductive power of the archaea right-handed coiled coil nanotube (RHCC-NT) and incorporation of mercury clusters inside protein cages
%J Journal of structural biology
%V 203
%N 3
%@ 1047-8477
%C San Diego, Calif.
%I Elsevier
%M PUBDB-2019-00829
%P 281 - 287
%D 2018
%Z © Elsevier Inc.
%X Coiled coils are well described as powerful oligomerization motifs and exhibit a large diversity of functions, including gene regulation, cell division, membrane fusion and drug extrusion. The archaea S-layer originated right-handed coiled coil –RHCC-NT- is characterized by extreme stability and is free of cysteine and histidine moieties. In the current study, we have followed a multidisciplinary approach to investigate the capacity of RHCC-NT to bind a variety of ionic complex metal ions. At the outside of the RHCC-NT, one mercury ion forms an electrostatic interaction with the S-methyl moiety of the single methionine residue present in each coil. We demonstrate that RHCC-NT is reducing and incorporating metallic mercury in the large-sized interior cavities which are lined up along the tetrameric channel.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29879486
%U <Go to ISI:>//WOS:000442713100012
%R 10.1016/j.jsb.2018.05.013
%U https://bib-pubdb1.desy.de/record/418925