Journal Article

PUBDB-2019-00167

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multimodal imaging platform for optical virtual skin biopsy enabled by a fiber-based two-color ultrafast laser source

Chung, H.-Y. (Corresponding author)Extern* ; Greinert, R. ; Kärtner, F. X.CFEL*Extern*DESY* ; Chang, G. (Corresponding author)Extern*

2019
OSA Washington, DC

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Please use a persistent id in citations: doi:10.1364/BOE.10.000514  doi:10.3204/PUBDB-2019-00167

Abstract: We demonstrate multimodal label-free nonlinear optical microscopy in human skin enabled by a fiber-based two-color ultrafast source. Energetic femtosecond pulses at 775 nm and 1250 nm are simultaneously generated by an Er-fiber laser source employing frequency doubling and self-phase modulation enabled spectral selection. The integrated nonlinear optical microscope driven by such a two-color femtosecond source enables the excitation of endogenous two-photon excitation fluorescence, second-harmonic generation, and third-harmonic generation in human skin. Such a 3-channel imaging platform constitutes a powerful tool for clinical application and optical virtual skin biopsy.

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Contributing Institute(s):

1. Ultrafast Lasers & X-rays Division (FS-CFEL-2)

Research Program(s):

1. 6211 - Extreme States of Matter: From Cold Ions to Hot Plasmas (POF3-621) (POF3-621)
2. VH-NG-804 - Towards Laboratory-Based Ultrafast Bright EUV and X-ray Sources (2015_IVF-VH-NG-804) (2015_IVF-VH-NG-804)
3. VH-VI-419 - Dynamic Pathways in Multidimensional Landscapes (VH-VI-419) (VH-VI-419)
4. HCJRG-201 - Advanced Laser Technologies for Ultrafast Spectroscopy of Quantum Materials (2015_IFV-HCJRG-201) (2015_IFV-HCJRG-201)
5. CUI - Hamburger Zentrum für ultraschnelle Beobachtung (194651731) (194651731)

Experiment(s):

1. No specific instrument

Appears in the scientific report 2019

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Engineering, Computing and Technology ; DOAJ Seal ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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