%0 Journal Article
%A Chung, Hsiang-Yu
%A Greinert, Rüdiger
%A Kärtner, Franz X.
%A Chang, Guoqing
%T Multimodal imaging platform for optical virtual skin biopsy enabled by a fiber-based two-color ultrafast laser source
%J Biomedical optics express
%V 10
%N 2
%@ 2156-7085
%C Washington, DC
%I OSA
%M PUBDB-2019-00167
%P 514 - 525
%D 2019
%X We demonstrate multimodal label-free nonlinear optical microscopy in human skin enabled by a fiber-based two-color ultrafast source. Energetic femtosecond pulses at 775 nm and 1250 nm are simultaneously generated by an Er-fiber laser source employing frequency doubling and self-phase modulation enabled spectral selection. The integrated nonlinear optical microscope driven by such a two-color femtosecond source enables the excitation of endogenous two-photon excitation fluorescence, second-harmonic generation, and third-harmonic generation in human skin. Such a 3-channel imaging platform constitutes a powerful tool for clinical application and optical virtual skin biopsy.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30800496
%U <Go to ISI:>//WOS:000457500300010
%R 10.1364/BOE.10.000514
%U https://bib-pubdb1.desy.de/record/418080