TY  - JOUR
AU  - Chung, Hsiang-Yu
AU  - Greinert, Rüdiger
AU  - Kärtner, Franz X.
AU  - Chang, Guoqing
TI  - Multimodal imaging platform for optical virtual skin biopsy enabled by a fiber-based two-color ultrafast laser source
JO  - Biomedical optics express
VL  - 10
IS  - 2
SN  - 2156-7085
CY  - Washington, DC
PB  - OSA
M1  - PUBDB-2019-00167
SP  - 514 - 525
PY  - 2019
AB  - We demonstrate multimodal label-free nonlinear optical microscopy in human skin enabled by a fiber-based two-color ultrafast source. Energetic femtosecond pulses at 775 nm and 1250 nm are simultaneously generated by an Er-fiber laser source employing frequency doubling and self-phase modulation enabled spectral selection. The integrated nonlinear optical microscope driven by such a two-color femtosecond source enables the excitation of endogenous two-photon excitation fluorescence, second-harmonic generation, and third-harmonic generation in human skin. Such a 3-channel imaging platform constitutes a powerful tool for clinical application and optical virtual skin biopsy.
LB  - PUB:(DE-HGF)16
C6  - pmid:30800496
UR  - <Go to ISI:>//WOS:000457500300010
DO  - DOI:10.1364/BOE.10.000514
UR  - https://bib-pubdb1.desy.de/record/418080
ER  -