Journal Article

PHPPUBDB-12175

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Essential Function of HP1$\beta$: A Case of the Tail Wagging the Dog?

Billur, M. ; Bartunik, H.Extern* ; Singh, P. B. (Corresponding author) ; DESY

2009
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.tibs.2009.09.003

Abstract: A large body of work in various organisms has shown that the presence of HP1 structural proteins and methylated lysine 9 of histone H3 (H3K9me) represent the characteristic hallmarks of heterochromatin. We propose that a more critical assessment of the physiological importance of the H3K9me-HP1 interaction is warranted in light of recent studies on the mammalian HP1 beta protein. Based on this new research, we conclude that the essential function of HP1 beta (and perhaps that of its orthologues in other species) lies outside the canonical heterochromatic H3K9me-HP1 interaction. We suggest instead that binding of a small fraction of HP1 beta to the H3 histone fold performs a critical role in heterochromatin function and organismal survival.

Keyword(s): Animals (MeSH) ; Chromosomal Proteins, Non-Histone: chemistry (MeSH) ; Chromosomal Proteins, Non-Histone: metabolism (MeSH) ; Histones: chemistry (MeSH) ; Histones: metabolism (MeSH) ; Humans (MeSH) ; Chromosomal Proteins, Non-Histone ; Histones ; heterochromatin-specific nonhistone chromosomal protein HP-1

Note: (c) Elsevier Ltd. Post referee full text in progress (embargo 1 year from 15 October 2009).

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Contributing Institute(s):

1. Experiments with synchrotron radiation (HASYLAB(-2012))
2. Max-Planck-Gesellschaft (MPG(-2012))

Research Program(s):

1. Facility (machine) DORIS/PETRA (POF1-DORIS-PETRA-20130405) (POF1-DORIS-PETRA-20130405)

Experiment(s):

1. Facility (machine) DORIS III

Appears in the scientific report 2009
Notes: (c) Elsevier. No copyright permission for full text.

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Database coverage:
; JCR ; No Author Disambiguation ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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