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000087275 1001_ $$0P:(DE-HGF)0$$aBillur, M.$$b0
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000087275 245__ $$aThe Essential Function of HP1$\beta$: A Case of the Tail Wagging the Dog?
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000087275 500__ $$3Converted on 2013-06-21 19:20
000087275 520__ $$aA large body of work in various organisms has shown that the presence of HP1 structural proteins and methylated lysine 9 of histone H3 (H3K9me) represent the characteristic hallmarks of heterochromatin. We propose that a more critical assessment of the physiological importance of the H3K9me-HP1 interaction is warranted in light of recent studies on the mammalian HP1 beta protein. Based on this new research, we conclude that the essential function of HP1 beta (and perhaps that of its orthologues in other species) lies outside the canonical heterochromatic H3K9me-HP1 interaction. We suggest instead that binding of a small fraction of HP1 beta to the H3 histone fold performs a critical role in heterochromatin function and organismal survival.
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000087275 650_7 $$00$$2NLM Chemicals$$aChromosomal Proteins, Non-Histone
000087275 650_7 $$00$$2NLM Chemicals$$aHistones
000087275 650_7 $$0107283-02-3$$2NLM Chemicals$$aheterochromatin-specific nonhistone chromosomal protein HP-1
000087275 650_2 $$2MeSH$$aAnimals
000087275 650_2 $$2MeSH$$aChromosomal Proteins, Non-Histone: chemistry
000087275 650_2 $$2MeSH$$aChromosomal Proteins, Non-Histone: metabolism
000087275 650_2 $$2MeSH$$aHistones: chemistry
000087275 650_2 $$2MeSH$$aHistones: metabolism
000087275 650_2 $$2MeSH$$aHumans
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000087275 7001_ $$0P:(DE-H253)PIP1003093$$aBartunik, Hans$$b1
000087275 7001_ $$0P:(DE-HGF)0$$aSingh, P. B.$$b2$$eCorresponding author
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