TY  - JOUR
AU  - Billur, M.
AU  - Bartunik, Hans
AU  - Singh, P. B.
AU  - DESY
TI  - The Essential Function of HP1β: A Case of the Tail Wagging the Dog?
JO  - Trends in biochemical sciences
VL  - 35
SN  - 0968-0004
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PHPPUBDB-12175
SP  - 115-123
PY  - 2009
N1  - (c) Elsevier Ltd. Post referee full text in progress (embargo 1 year from 15 October 2009).
AB  - A large body of work in various organisms has shown that the presence of HP1 structural proteins and methylated lysine 9 of histone H3 (H3K9me) represent the characteristic hallmarks of heterochromatin. We propose that a more critical assessment of the physiological importance of the H3K9me-HP1 interaction is warranted in light of recent studies on the mammalian HP1 beta protein. Based on this new research, we conclude that the essential function of HP1 beta (and perhaps that of its orthologues in other species) lies outside the canonical heterochromatic H3K9me-HP1 interaction. We suggest instead that binding of a small fraction of HP1 beta to the H3 histone fold performs a critical role in heterochromatin function and organismal survival.
KW  - Animals
KW  - Chromosomal Proteins, Non-Histone: chemistry
KW  - Chromosomal Proteins, Non-Histone: metabolism
KW  - Histones: chemistry
KW  - Histones: metabolism
KW  - Humans
KW  - Chromosomal Proteins, Non-Histone (NLM Chemicals)
KW  - Histones (NLM Chemicals)
KW  - heterochromatin-specific nonhistone chromosomal protein HP-1 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:19836960
UR  - <Go to ISI:>//WOS:000274714300007
DO  - DOI:10.1016/j.tibs.2009.09.003
UR  - https://bib-pubdb1.desy.de/record/87275
ER  -