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| 005 | 20250731122211.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:19836960 |
| 024 | 7 | _ | |2 ISSN |a 0968-0004 |
| 024 | 7 | _ | |2 ISSN |a 1362-4326 |
| 024 | 7 | _ | |2 WOS |a WOS:000274714300007 |
| 024 | 7 | _ | |2 doi |a 10.1016/j.tibs.2009.09.003 |
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| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Billur, M. |b 0 |
| 110 | 1 | _ | |a DESY |b Experiments with synchrotron radiation |
| 245 | _ | _ | |a The Essential Function of HP1$\beta$: A Case of the Tail Wagging the Dog? |
| 260 | _ | _ | |a Amsterdam [u.a.] |b Elsevier Science |c 2009 |
| 300 | _ | _ | |a 115-123 |
| 336 | 7 | _ | |2 DRIVER |a article |
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| 336 | 7 | _ | |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |a Journal Article |b journal |m journal |s 1481731289_13415 |
| 336 | 7 | _ | |2 BibTeX |a ARTICLE |
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| 336 | 7 | _ | |0 0 |2 EndNote |a Journal Article |
| 440 | _ | 0 | |0 PERI:(DE-600)1498901-3 |a Trends Biochem. Sci. |v 35 |x 0968-0004 |
| 500 | _ | _ | |3 Converted on 2013-05-30 12:56 |a (c) Elsevier Ltd. Post referee full text in progress (embargo 1 year from 15 October 2009). |
| 500 | _ | _ | |3 Converted on 2013-06-21 19:20 |
| 520 | _ | _ | |a A large body of work in various organisms has shown that the presence of HP1 structural proteins and methylated lysine 9 of histone H3 (H3K9me) represent the characteristic hallmarks of heterochromatin. We propose that a more critical assessment of the physiological importance of the H3K9me-HP1 interaction is warranted in light of recent studies on the mammalian HP1 beta protein. Based on this new research, we conclude that the essential function of HP1 beta (and perhaps that of its orthologues in other species) lies outside the canonical heterochromatic H3K9me-HP1 interaction. We suggest instead that binding of a small fraction of HP1 beta to the H3 histone fold performs a critical role in heterochromatin function and organismal survival. |
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| 588 | _ | _ | |a Dataset connected to Pubmed |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Chromosomal Proteins, Non-Histone |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Histones |
| 650 | _ | 7 | |0 107283-02-3 |2 NLM Chemicals |a heterochromatin-specific nonhistone chromosomal protein HP-1 |
| 650 | _ | 2 | |2 MeSH |a Animals |
| 650 | _ | 2 | |2 MeSH |a Chromosomal Proteins, Non-Histone: chemistry |
| 650 | _ | 2 | |2 MeSH |a Chromosomal Proteins, Non-Histone: metabolism |
| 650 | _ | 2 | |2 MeSH |a Histones: chemistry |
| 650 | _ | 2 | |2 MeSH |a Histones: metabolism |
| 650 | _ | 2 | |2 MeSH |a Humans |
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| 700 | 1 | _ | |0 P:(DE-H253)PIP1003093 |a Bartunik, Hans |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Singh, P. B. |b 2 |e Corresponding author |
| 773 | _ | _ | |0 PERI:(DE-600)1498901-3 |a 10.1016/j.tibs.2009.09.003 |g Vol. 35, p. 115-123 |p 115-123 |q 35<115-123 |t Trends in biochemical sciences |v 35 |x 0968-0004 |y 2009 |
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| 914 | 1 | _ | |a (c) Elsevier. No copyright permission for full text. |y 2009 |
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