Journal Article

PUBDB-2025-04007

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Kinetics of light-induced mesophase transitions in azobenzene amphiphiles containing lyotropic liquid crystals

Hoevelmann, S. C. (Corresponding author)Extern*DESY* ; Röhrl, M. ; Dieball, E. ; Dargasz, M. ; Kuhn, J. ; Giri, R. P. ; Reise, F. ; Soloviov, D.EMBL* ; Blanchet, C.Extern*EMBL* ; Paulus, M. ; Lindhorst, T. K. ; Murphy, B. (Corresponding author)Extern*XFEL.EU*DESY*

2025
Munksgaard Copenhagen

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Please use a persistent id in citations: doi:10.1107/S1600576725004923  doi:10.3204/PUBDB-2025-04007

Abstract: This study focuses on the kinetics of light-induced mesophase transitions in lyotropic liquid crystals containing a mixture of phospho­lipids and azo­benzene amphiphiles. Lipid membranes organize in a wide range of morphologies, directly influencing their functionality and the efficiency of associated components such as proteins. Transitions between mesophases occur naturally during membrane fusion and can also be triggered by multiple factors, such as pH, salinity, temperature and light. Employing light to isomerize artificial photoswitchable lipids in mixed model membranes containing 1,2-dipalmitoyl­phos­pha­tidylcholine or 1,2-didecanoyl­phosphatidylcholine revealed light-induced structural changes including mesophase transitions from a lamellar to a cubic Pn3m phase. Performing time-resolved small-angle X-ray scattering measurements, the kinetics of the change in membrane repeat distance and the transition from a lamellar to a bicontinuous cubic phase could be captured on the timescale of tens of seconds. The results demonstrate new possibilities for investigating intermediate states during mesophase transitions that are important to understand membrane fusion, and they highlight the potential of photoswitchable lipids for designing bespoke drug delivery systems.

Note: DeutscheForschungsgemeinschaft (DFG, German Research Founda-tion) project No. 460248799. The following additional fundingis acknowledged: Deutsche Forschungsgemeinschaft (grantNo. SFB 677); Bundesministerium fu¨ r Bildung und Forschung,ErUM Pro (grant Nos. 05K22FK3 and 05K19FK2).

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Contributing Institute(s):

1. EMBL-User (EMBL-User)
2. EMBL (EMBL)
3. Scientific computing (FS-SC)

Research Program(s):

1. 632 - Materials – Quantum, Complex and Functional Materials (POF4-632) (POF4-632)
2. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
3. DFG project G:(GEPRIS)460248799 - DAPHNE4NFDI - DAten aus PHoton- und Neutronen Experimenten für NFDI (460248799) (460248799)
4. DFG project G:(GEPRIS)13266514 - SFB 677: Funktion durch Schalten (13266514) (13266514)
5. 05K22FK3 - LISA-dymanics: Aufbau für die Untersuchung von schneller und ultraschneller Dynamik an flüssigen Grenzflächen mittels optischer Pump-Röntgen-Probe Techniken. (BMBF-05K22FK3) (BMBF-05K22FK3)

Experiment(s):

1. PETRA Beamline P12 (PETRA III)

Appears in the scientific report 2025

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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