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@ARTICLE{Hvelmann:638189,
author = {Hövelmann, Svenja C. and Röhrl, Michael and Dieball, Ella
and Dargasz, Michelle and Kuhn, Jule and Giri, Rajendra P.
and Reise, Franziska and Soloviov, Dmytro and Blanchet,
Clement and Paulus, Michael and Lindhorst, Thisbe K. and
Murphy, Bridget M.},
title = {{K}inetics of light-induced mesophase transitions in
azobenzene amphiphiles containing lyotropic liquid crystals},
journal = {Journal of applied crystallography},
volume = {58},
number = {4},
issn = {0021-8898},
address = {Copenhagen},
publisher = {Munksgaard},
reportid = {PUBDB-2025-04007},
pages = {1322 - 1331},
year = {2025},
abstract = {This study focuses on the kinetics of light-induced
mesophase transitions in lyotropic liquid crystals
containing a mixture of phospholipids and azobenzene
amphiphiles. Lipid membranes organize in a wide range of
morphologies, directly influencing their functionality and
the efficiency of associated components such as proteins.
Transitions between mesophases occur naturally during
membrane fusion and can also be triggered by multiple
factors, such as pH, salinity, temperature and light.
Employing light to isomerize artificial photoswitchable
lipids in mixed model membranes containing
1,2-dipalmitoylphosphatidylcholine or
1,2-didecanoylphosphatidylcholine revealed light-induced
structural changes including mesophase transitions from a
lamellar to a cubic Pn3m phase. Performing time-resolved
small-angle X-ray scattering measurements, the kinetics of
the change in membrane repeat distance and the transition
from a lamellar to a bicontinuous cubic phase could be
captured on the timescale of tens of seconds. The results
demonstrate new possibilities for investigating intermediate
states during mesophase transitions that are important to
understand membrane fusion, and they highlight the potential
of photoswitchable lipids for designing bespoke drug
delivery systems.},
cin = {EMBL-User / EMBL},
ddc = {540},
cid = {I:(DE-H253)EMBL-User-20120814 / I:(DE-H253)EMBL-20120731},
pnm = {6G3 - PETRA III (DESY) (POF4-6G3)},
pid = {G:(DE-HGF)POF4-6G3},
experiment = {EXP:(DE-H253)P-P12-20150101},
typ = {PUB:(DE-HGF)16},
doi = {10.1107/S1600576725004923},
url = {https://bib-pubdb1.desy.de/record/638189},
}