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| Home > Publications database > A 250 Hz fast shutter with flexible sampling schemes for low-dose XPCS experiments at beamline P10 at PETRA III |
| Journal Article | PUBDB-2025-02614 |
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2025
IOP Publ.
Bristol
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Please use a persistent id in citations: doi:10.1088/1742-6596/3010/1/012095 doi:10.3204/PUBDB-2025-02614
Abstract: Low-dose X-ray photon correlation spectroscopy experiments on biological samples can be used to investigate the structure formation and underlying dynamics during phase separation, denaturation, and gelation. However, the use of intensive X-ray beams as an investigative tool is limited due to the susceptibility of biological samples to radiation-induced changes. XPCS in particular requires recording a series of high-frame-rate images to capture fast dynamics. In such cases, a fast X-ray shutter system is required to minimize beam damage to the samples by allowing a flexible delay between two images. Here we show how a fast (250 Hz) X-ray shutter system, built by the University of Siegen in close collaboration with DESY, improves low-dose XPCS capabilities at the P10 beamline at PETRA III. We found that by employing this shutter system in a logarithmic sampling scheme, the absorbed X-ray dose on the samples could be significantly decreased.
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