Journal Article

PUBDB-2025-00386

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Base-pairing of uracil and 2,6-diaminopurine: from cocrystals to photoreactivity

Stolar, T.Extern* ; Pearce, B. K. D. ; Etter, M.DESY* ; Truong, K.-N. ; Ostojić, T. ; Krajnc, A. ; Mali, G.Extern* ; Rossi, B.Extern* ; Molčanov, K. ; Lončarić, I. ; Meštrović, E. ; Uzarevic, K. (Corresponding author)Extern* ; Grisanti, L. (Corresponding author)

2024
Elsevier St. Louis

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Please use a persistent id in citations: doi:10.1016/j.isci.2024.109894  doi:10.3204/PUBDB-2025-00386

Abstract: We show that the non-canonical nucleobase 2,6-diaminopurine (D) spontaneously base pairs with uracil (U) in water and the solid state without the need to be attached to the ribose-phosphate backbone. Depending on the reaction conditions, D and U assemble in thermodynamically stable hydrated and anhydrated D-U base-paired cocrystals. Under UV irradiation, an aqueous solution of D-U base-pair undergoes photochemical degradation, while a pure aqueous solution of U does not. Our simulations suggest that D may trigger the U photodimerization and show that complementary base-pairing modifies the photochemical properties of nucleobases, which might have implications for prebiotic chemistry.

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)
2. PETRA-D (FS-PETRA-D)

Research Program(s):

1. 632 - Materials – Quantum, Complex and Functional Materials (POF4-632) (POF4-632)
2. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
3. FS-Proposal: I-20220019 EC (I-20220019-EC) (I-20220019-EC)

Experiment(s):

1. PETRA Beamline P02.1 (PETRA III)

Appears in the scientific report 2024

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