TY  - JOUR
AU  - Stolar, Tomislav
AU  - Pearce, Ben K. D.
AU  - Etter, Martin
AU  - Truong, Khai-Nghi
AU  - Ostojić, Tea
AU  - Krajnc, Andraž
AU  - Mali, Gregor
AU  - Rossi, Barbara
AU  - Molčanov, Krešimir
AU  - Lončarić, Ivor
AU  - Meštrović, Ernest
AU  - Uzarevic, Krunoslav
AU  - Grisanti, Luca
TI  - Base-pairing of uracil and 2,6-diaminopurine: from cocrystals to photoreactivity
JO  - iScience
VL  - 27
IS  - 6
SN  - 2589-0042
CY  - St. Louis
PB  - Elsevier
M1  - PUBDB-2025-00386
SP  - 109894
PY  - 2024
AB  - We show that the non-canonical nucleobase 2,6-diaminopurine (D) spontaneously base pairs with uracil (U) in water and the solid state without the need to be attached to the ribose-phosphate backbone. Depending on the reaction conditions, D and U assemble in thermodynamically stable hydrated and anhydrated D-U base-paired cocrystals. Under UV irradiation, an aqueous solution of D-U base-pair undergoes photochemical degradation, while a pure aqueous solution of U does not. Our simulations suggest that D may trigger the U photodimerization and show that complementary base-pairing modifies the photochemical properties of nucleobases, which might have implications for prebiotic chemistry.
LB  - PUB:(DE-HGF)16
C6  - pmid:38783999
UR  - <Go to ISI:>//WOS:001243820300001
DO  - DOI:10.1016/j.isci.2024.109894
UR  - https://bib-pubdb1.desy.de/record/622549
ER  -