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@ARTICLE{Stolar:622549,
author = {Stolar, Tomislav and Pearce, Ben K. D. and Etter, Martin
and Truong, Khai-Nghi and Ostojić, Tea and Krajnc, Andraž
and Mali, Gregor and Rossi, Barbara and Molčanov, Krešimir
and Lončarić, Ivor and Meštrović, Ernest and Uzarevic,
Krunoslav and Grisanti, Luca},
title = {{B}ase-pairing of uracil and 2,6-diaminopurine: from
cocrystals to photoreactivity},
journal = {iScience},
volume = {27},
number = {6},
issn = {2589-0042},
address = {St. Louis},
publisher = {Elsevier},
reportid = {PUBDB-2025-00386},
pages = {109894},
year = {2024},
abstract = {We show that the non-canonical nucleobase 2,6-diaminopurine
(D) spontaneously base pairs with uracil (U) in water and
the solid state without the need to be attached to the
ribose-phosphate backbone. Depending on the reaction
conditions, D and U assemble in thermodynamically stable
hydrated and anhydrated D-U base-paired cocrystals. Under UV
irradiation, an aqueous solution of D-U base-pair undergoes
photochemical degradation, while a pure aqueous solution of
U does not. Our simulations suggest that D may trigger the U
photodimerization and show that complementary base-pairing
modifies the photochemical properties of nucleobases, which
might have implications for prebiotic chemistry.},
cin = {DOOR ; HAS-User / FS-PETRA-D},
ddc = {050},
cid = {I:(DE-H253)HAS-User-20120731 /
I:(DE-H253)FS-PETRA-D-20210408},
pnm = {632 - Materials – Quantum, Complex and Functional
Materials (POF4-632) / 6G3 - PETRA III (DESY) (POF4-6G3) /
FS-Proposal: I-20220019 EC (I-20220019-EC)},
pid = {G:(DE-HGF)POF4-632 / G:(DE-HGF)POF4-6G3 /
G:(DE-H253)I-20220019-EC},
experiment = {EXP:(DE-H253)P-P02.1-20150101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:38783999},
UT = {WOS:001243820300001},
doi = {10.1016/j.isci.2024.109894},
url = {https://bib-pubdb1.desy.de/record/622549},
}