Journal Article

PUBDB-2021-04550

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model

Qiao, J. (Corresponding author) ; Li, Y.-S.Extern*EMBL* ; Zeng, R. ; Liu, F.-L.Extern* ; Luo, R.-H. ; Huang, C. ; Wang, Y.-F. ; Zhang, J. ; Quan, B. ; Shen, C. ; Mao, X.Extern* ; Liu, X. ; Sun, W. ; Yang, W.Extern* ; Ni, X. ; Wang, K.Extern* ; Xu, L.Extern* ; Duan, Z.-L. ; Zou, Q.-C. ; Zhang, H.-L. ; Qu, W. ; Long, Y.-H.-P. ; Li, M.-H. ; Yang, R.-C. ; Liu, X. ; You, J. ; Zhou, Y. ; Yao, R. ; Li, W.-P. ; Liu, J.-M. ; Chen, P. ; Liu, Y. ; Lin, G.-F. ; Yang, X. ; Zou, J. ; Li, L. ; Hu, Y. ; Lu, G.-W. ; Li, W.-M. ; Wei, Y.-Q. ; Zheng, Y.-T. ; Lei, J. ; Yang, S.

2021
Moses King Cambridge, Mass.

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Please use a persistent id in citations: doi:10.1126/science.abf1611  doi:10.3204/PUBDB-2021-04550

Abstract: Vaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines. The viral protein main protease is required for cleaving precursor polyproteins into functional viral proteins. This essential function makes it a key drug target. Qiao et al. designed 32 inhibitors based on either boceprevir or telaprevir, both of which are protease inhibitors approved to treat hepatitis C virus. Six compounds protected cells from viral infection with high potency, and two of these were selected for in vivo studies based on pharmokinetic experiments. Both showed strong antiviral activity in a mouse model.

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)

Experiment(s):

1. PETRA Beamline P11 (PETRA III)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 40 ; Index Chemicus ; JCR ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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