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000471682 1001_ $$00000-0002-8617-5148$$aQiao, Jingxin$$b0$$eCorresponding author
000471682 245__ $$aSARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model
000471682 260__ $$aCambridge, Mass.$$bMoses King$$c2021
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000471682 520__ $$aVaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines. The viral protein main protease is required for cleaving precursor polyproteins into functional viral proteins. This essential function makes it a key drug target. Qiao et al. designed 32 inhibitors based on either boceprevir or telaprevir, both of which are protease inhibitors approved to treat hepatitis C virus. Six compounds protected cells from viral infection with high potency, and two of these were selected for in vivo studies based on pharmokinetic experiments. Both showed strong antiviral activity in a mouse model.
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000471682 7001_ $$0P:(DE-H253)PIP1089163$$aLi, Yue-Shan$$b1
000471682 7001_ $$00000-0001-9716-6354$$aZeng, Rui$$b2
000471682 7001_ $$0P:(DE-H253)PIP1081794$$aLiu, Feng-Liang$$b3
000471682 7001_ $$00000-0001-9173-9991$$aLuo, Rong-Hua$$b4
000471682 7001_ $$00000-0003-0951-3411$$aHuang, Chong$$b5
000471682 7001_ $$aWang, Yi-Fei$$b6
000471682 7001_ $$aZhang, Jie$$b7
000471682 7001_ $$00000-0002-7312-2645$$aQuan, Baoxue$$b8
000471682 7001_ $$00000-0002-7521-4068$$aShen, Chenjian$$b9
000471682 7001_ $$0P:(DE-H253)PIP1080614$$aMao, Xin$$b10
000471682 7001_ $$00000-0001-7216-9292$$aLiu, Xinlei$$b11
000471682 7001_ $$00000-0002-3395-7840$$aSun, Weining$$b12
000471682 7001_ $$0P:(DE-H253)PIP1097882$$aYang, Wei$$b13
000471682 7001_ $$00000-0002-9723-4756$$aNi, Xincheng$$b14
000471682 7001_ $$0P:(DE-H253)PIP1030760$$aWang, Kai$$b15
000471682 7001_ $$0P:(DE-H253)PIP1025817$$aXu, Ling$$b16
000471682 7001_ $$00000-0002-3262-9685$$aDuan, Zi-Lei$$b17
000471682 7001_ $$00000-0002-2381-9532$$aZou, Qing-Cui$$b18
000471682 7001_ $$aZhang, Hai-Lin$$b19
000471682 7001_ $$00000-0003-4041-9634$$aQu, Wang$$b20
000471682 7001_ $$00000-0002-4167-746X$$aLong, Yang-Hao-Peng$$b21
000471682 7001_ $$aLi, Ming-Hua$$b22
000471682 7001_ $$aYang, Rui-Cheng$$b23
000471682 7001_ $$00000-0003-1531-702X$$aLiu, Xiaolong$$b24
000471682 7001_ $$00000-0001-9489-8947$$aYou, Jing$$b25
000471682 7001_ $$00000-0002-9800-7766$$aZhou, Yangli$$b26
000471682 7001_ $$00000-0003-4858-3551$$aYao, Rui$$b27
000471682 7001_ $$aLi, Wen-Pei$$b28
000471682 7001_ $$aLiu, Jing-Ming$$b29
000471682 7001_ $$00000-0002-7710-6837$$aChen, Pei$$b30
000471682 7001_ $$aLiu, Yang$$b31
000471682 7001_ $$00000-0002-2888-6099$$aLin, Gui-Feng$$b32
000471682 7001_ $$aYang, Xin$$b33
000471682 7001_ $$00000-0002-5395-6052$$aZou, Jun$$b34
000471682 7001_ $$00000-0001-7743-434X$$aLi, Linli$$b35
000471682 7001_ $$00000-0002-3973-2140$$aHu, Yiguo$$b36
000471682 7001_ $$00000-0001-7568-592X$$aLu, Guang-Wen$$b37
000471682 7001_ $$aLi, Wei-Min$$b38
000471682 7001_ $$00000-0002-6211-3217$$aWei, Yu-Quan$$b39
000471682 7001_ $$00000-0001-5469-0324$$aZheng, Yong-Tang$$b40
000471682 7001_ $$aLei, Jian$$b41
000471682 7001_ $$00000-0001-5147-3746$$aYang, Shengyong$$b42
000471682 773__ $$0PERI:(DE-600)2066996-3$$a10.1126/science.abf1611$$gVol. 371, no. 6536, p. 1374 - 1378$$n6536$$p1374 - 1378$$tScience$$v371$$x0036-8075$$y2021
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