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Journal Article PUBDB-2021-00075
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3D diffractive imaging of nanoparticle ensembles using an x-ray laser

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2021
OSA Washington, DC

Optica 8(1), 15 - 23 () [10.1364/OPTICA.410851]
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Abstract: Single particle imaging at x-ray free electron lasers (XFELs) has the potential to determine the structure and dynamics of single biomolecules at room temperature. Two major hurdles have prevented this potential from being reached, namely, the collection of sufficient high-quality diffraction patterns and robust computational purification to overcome structural heterogeneity. We report the breaking of both of these barriers using gold nanoparticle test samples, recording around 10 million diffraction patterns at the European XFEL and structurally and orientationally sorting the patterns to obtain better than 3-nm-resolution 3D reconstructions for each of four samples. With these new developments, integrating advancements in x-ray sources, fast-framing detectors, efficient sample delivery, and data analysis algorithms, we illuminate the path towards sub-nanometer biomolecular imaging. The methods developed here can also be extended to characterize ensembles that are inherently diverse to obtain their full structural landscape.

Classification:

Note: 5 main figures, 6 supplementary figures, 2 supplementary movies (link in document)
Contributing Institute(s):
  1. FS-CFEL-1 (Group Leader: Henry Chapman) (CFEL-I)
  2. CFEL-Coherent X-Ray Imaging (FS-CFEL-1)
  3. CFEL-CMI (FS-CFEL-CMI)
  4. beauftragt von UNI (UNI/CUI)
  5. Uni Hamburg / Experimentalphysik (UNI/EXP)
Research Program(s):
  1. 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633) (POF4-633)
  2. DFG project 194651731 - EXC 1074: Hamburger Zentrum für ultraschnelle Beobachtung (CUI): Struktur, Dynamik und Kontrolle von Materie auf atomarer Skala (194651731) (194651731)
  3. DFG project 390715994 - EXC 2056: CUI: Advanced Imaging of Matter (390715994) (390715994)
  4. COMOTION - Controlling the Motion of Complex Molecules and Particles (614507) (614507)
Experiment(s):
  1. Experiments at XFEL

Appears in the scientific report 2021
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Medline ; Creative Commons Attribution CC BY 4.0 ; DOAJ ; OpenAccess ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
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Private Collections > >Extern > >HAS-User > >FS-UNI > UNI/CUI
Private Collections > >Extern > >HAS-User > >FS-UNI > UNI/EXP
Private Collections > >CFEL > >FS-CFEL > CFEL-I
Private Collections > >DESY > >FS > FS-CFEL-CMI
Private Collections > >DESY > >FS > FS-CFEL-1
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3D diffractive imaging of nanoparticle ensembles using an X-ray laser
1-25 () [10.3204/PUBDB-2020-02854]  GO OpenAccess  Download fulltext Files  Download fulltextFulltext by arXiv.org BibTeX | EndNote: XML, Text | RIS

 Record created 2021-01-05, last modified 2025-07-16
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