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@ARTICLE{Ayyer:453632,
      author       = {Ayyer, Kartik and Paulraj, Lourdu Xavier and Bielecki,
                      Johan and Shen, Zhou and Daurer, Benedikt J. and Samanta,
                      Amit K. and Awel, Salah and Bean, Richard and Barty, Anton
                      and Bergemann, Martin and Ekeberg, Tomas and Estillore,
                      Armando D. and Fangohr, Hans and Giewekemeyer, Klaus and
                      Hunter, Mark S. and Karnevskiy, Mikhail and Kirian, Richard
                      and Kirkwood, Henry and Kim, Yoonhee and Koliyadu, Jayanath
                      and Lange, Holger and Letrun, Romain and Luebke, Jannik and
                      Michelat, Thomas and Morgan, Andrew J. and Roth, Nils and
                      Sato, Tokushi and Sikorski, Marcin and Schulz, Florian and
                      Spence, John C. H. and Vagovic, Patrik and Wollweber, Tamme
                      and Worbs, Lena and Yefanov, Oleksandr and Zhuang, Yulong
                      and Maia, Filipe R. N. C. and Horke, Daniel A. and Küpper,
                      Jochen and Loh, N. Duane and Mancuso, Adrian P. and Chapman,
                      Henry N.},
      title        = {3{D} diffractive imaging of nanoparticle ensembles using an
                      x-ray laser},
      journal      = {Optica},
      volume       = {8},
      number       = {1},
      issn         = {2334-2536},
      address      = {Washington, DC},
      publisher    = {OSA},
      reportid     = {PUBDB-2021-00075},
      pages        = {15 - 23},
      year         = {2021},
      note         = {5 main figures, 6 supplementary figures, 2 supplementary
                      movies (link in document)},
      abstract     = {Single particle imaging at x-ray free electron lasers
                      (XFELs) has the potential to determine the structure and
                      dynamics of single biomolecules at room temperature. Two
                      major hurdles have prevented this potential from being
                      reached, namely, the collection of sufficient high-quality
                      diffraction patterns and robust computational purification
                      to overcome structural heterogeneity. We report the breaking
                      of both of these barriers using gold nanoparticle test
                      samples, recording around 10 million diffraction patterns at
                      the European XFEL and structurally and orientationally
                      sorting the patterns to obtain better than 3-nm-resolution
                      3D reconstructions for each of four samples. With these new
                      developments, integrating advancements in x-ray sources,
                      fast-framing detectors, efficient sample delivery, and data
                      analysis algorithms, we illuminate the path towards
                      sub-nanometer biomolecular imaging. The methods developed
                      here can also be extended to characterize ensembles that are
                      inherently diverse to obtain their full structural
                      landscape.},
      cin          = {CFEL-I / FS-CFEL-1 / FS-CFEL-CMI / UNI/CUI / UNI/EXP},
      ddc          = {620},
      cid          = {I:(DE-H253)CFEL-I-20161114 / I:(DE-H253)FS-CFEL-1-20120731
                      / I:(DE-H253)FS-CFEL-CMI-20220405 /
                      $I:(DE-H253)UNI_CUI-20121230$ /
                      $I:(DE-H253)UNI_EXP-20120731$},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / DFG project 194651731 - EXC 1074:
                      Hamburger Zentrum für ultraschnelle Beobachtung (CUI):
                      Struktur, Dynamik und Kontrolle von Materie auf atomarer
                      Skala (194651731) / DFG project 390715994 - EXC 2056: CUI:
                      Advanced Imaging of Matter (390715994) / COMOTION -
                      Controlling the Motion of Complex Molecules and Particles
                      (614507)},
      pid          = {G:(DE-HGF)POF4-633 / G:(GEPRIS)194651731 /
                      G:(GEPRIS)390715994 / G:(EU-Grant)614507},
      experiment   = {EXP:(DE-H253)XFEL-Exp-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000610085000003},
      doi          = {10.1364/OPTICA.410851},
      url          = {https://bib-pubdb1.desy.de/record/453632},
}