Journal Article

PUBDB-2020-05317

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Design study for a compact laser-driven source for medical x-ray fluorescence imaging

Brümmer, T. (Corresponding author)CFEL*Extern*DESY* ; Debus, A. ; Pausch, R. ; Osterhoff, J.DESY* ; Grüner, F.CFEL*Extern*

2020
American Physical Society College Park, MD

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Please use a persistent id in citations: doi:10.1103/PhysRevAccelBeams.23.031601  doi:10.3204/PUBDB-2020-05317

Abstract: Thomson scattering sources with their hard x-ray pencil beams represent a promising candidate to drivehigh-resolution X-ray Fluorescence Imaging (XFI). As XFI is a scanning imaging modality, it specificallyrequires pencil-beam geometries along with a high beam mobility. In combination with laser-wakefieldacceleration (LWFA) such sources could provide the compactness needed for a future transition intoclinical application. A sufficient flux within a small bandwidth could enable in-vivo high-sensitivity XFIfor early cancer diagnostics and pharmacokinetic imaging. We thus report on a specific all-laser drivensource design directed at increasing the photon number within the bandwidth and opening angle defined byXFI conditions. Typical parameters of driver lasers and electron bunches from LWFA are utilized andcontrolled within realistic parameter regions on the basis of appropriate beam optics. An active plasma lensis implemented for chromatic focal control of the bunch. Source performance limits are identified andcompared to existing x-ray sources with regard to their potential to be implemented in future clinical XFI.

Keyword(s): Design Studies

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Contributing Institute(s):

1. Forschung Linear Accelerator (FLA)
2. Plasma Accelerators (MPA)
3. beautragt von UNI/EXP (CFEL-NOVA)

Research Program(s):

1. 631 - Accelerator R & D (POF3-631) (POF3-631)
2. PWA - Research group for plasma-based accelerators (PWA-20150304) (PWA-20150304)

Experiment(s):

1. FLASHForward

Appears in the scientific report 2020

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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