TY  - JOUR
AU  - Brümmer, Theresa
AU  - Debus, Alexander
AU  - Pausch, Richard
AU  - Osterhoff, Jens
AU  - Grüner, Florian
TI  - Design study for a compact laser-driven source for medical x-ray fluorescence imaging
JO  - Physical review accelerators and beams
VL  - 23
IS  - 3
SN  - 2469-9888
CY  - College Park, MD
PB  - American Physical Society
M1  - PUBDB-2020-05317
SP  - 031601
PY  - 2020
AB  - Thomson scattering sources with their hard x-ray pencil beams represent a promising candidate to drivehigh-resolution X-ray Fluorescence Imaging (XFI). As XFI is a scanning imaging modality, it specificallyrequires pencil-beam geometries along with a high beam mobility. In combination with laser-wakefieldacceleration (LWFA) such sources could provide the compactness needed for a future transition intoclinical application. A sufficient flux within a small bandwidth could enable in-vivo high-sensitivity XFIfor early cancer diagnostics and pharmacokinetic imaging. We thus report on a specific all-laser drivensource design directed at increasing the photon number within the bandwidth and opening angle defined byXFI conditions. Typical parameters of driver lasers and electron bunches from LWFA are utilized andcontrolled within realistic parameter regions on the basis of appropriate beam optics. An active plasma lensis implemented for chromatic focal control of the bunch. Source performance limits are identified andcompared to existing x-ray sources with regard to their potential to be implemented in future clinical XFI.
KW  - Design Studies (autogen)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000517431500001
DO  - DOI:10.1103/PhysRevAccelBeams.23.031601
UR  - https://bib-pubdb1.desy.de/record/453521
ER  -