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| Journal Article | PUBDB-2015-01173 |
; ; ; ;
2014
Royal Soc. of Chemistry
London
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Please use a persistent id in citations: doi:10.1039/C4SM00530A
Abstract: Small- and wide-angle X-ray diffraction was used to study the effect of 1-alkanols, as simple models of general anesthetics, (abbreviation $C_{n}OH$, n = 8–18 is the even number of carbons in the aliphatic chain) on the lamellar to hexagonal $L\alpha \rightarrow H_{II}$ phase transition in the dioleoylphosphatidylethanolamine–dioleoylphosphatidylcholine = 3 : 1 mol/mol (DOPE + DOPC) system. All studied $C_{n}OHs$ were found to decrease the phase transition temperature of the DOPE + DOPC system in a $C_{n}OH$ chain length and concentration dependent manner and thus promote the formation of the $H_{II}$ phase. Anesthetically active $C_{8}OH$ and $C_{10}OH$ were found to decrease the lattice parameter $\mathit{d}$ of the $L\alpha$ phase, however longer non-anesthetic CnOHs increased the parameter $\mathit{d}$; this effect being more pronounced with increasing $C_{n}OH$ concentration. The lattice parameter $\mathit{a}$ of the $H_{II}$ phase was decreased in the presence of all $C_{n}OHs$, even at the lowest concentrations studied. In the scope of the indirect mechanism of general anesthesia observed changes in the lattice parameter $\mathit{d}$ (reflecting changes in the bilayer thickness) due to the intercalation of $C_{8}OH$ and $C_{10}OH$ might induce changes in the activity of integral membrane proteins engaged in neuronal pathways.
; Allianz-Lizenz / DFG ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; Nationallizenz
; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection
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