Home > Publications database > Phase Behavior of the DOPE + DOPC + Alkanol System > print

001     207189
005     20250730145657.0
024 7 _ |a 10.1039/C4SM00530A
|2 doi
024 7 _ |a 1744-683X
|2 ISSN
024 7 _ |a 1744-6848
|2 ISSN
024 7 _ |a WOS:000340428700021
|2 WOS
024 7 _ |a pmid:24980804
|2 pmid
024 7 _ |a openalex:W2029360354
|2 openalex
037 _ _ |a PUBDB-2015-01173
082 _ _ |a 530
100 1 _ |a Klacsová, Mária
|0 P:(DE-HGF)0
|b 0
|e Corresponding Author
245 _ _ |a Phase Behavior of the DOPE + DOPC + Alkanol System
260 _ _ |a London
|c 2014
|b Royal Soc. of Chemistry
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a article
|2 DRIVER
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1462365096_5568
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
500 _ _ |a (c) The Royal Society of Chemistry. Post referee full text in progress.
520 _ _ |a Small- and wide-angle X-ray diffraction was used to study the effect of 1-alkanols, as simple models of general anesthetics, (abbreviation $C_{n}OH$, n = 8–18 is the even number of carbons in the aliphatic chain) on the lamellar to hexagonal $L\alpha \rightarrow H_{II}$ phase transition in the dioleoylphosphatidylethanolamine–dioleoylphosphatidylcholine = 3 : 1 mol/mol (DOPE + DOPC) system. All studied $C_{n}OHs$ were found to decrease the phase transition temperature of the DOPE + DOPC system in a $C_{n}OH$ chain length and concentration dependent manner and thus promote the formation of the $H_{II}$ phase. Anesthetically active $C_{8}OH$ and $C_{10}OH$ were found to decrease the lattice parameter $\mathit{d}$ of the $L\alpha$ phase, however longer non-anesthetic CnOHs increased the parameter $\mathit{d}$; this effect being more pronounced with increasing $C_{n}OH$ concentration. The lattice parameter $\mathit{a}$ of the $H_{II}$ phase was decreased in the presence of all $C_{n}OHs$, even at the lowest concentrations studied. In the scope of the indirect mechanism of general anesthesia observed changes in the lattice parameter $\mathit{d}$ (reflecting changes in the bilayer thickness) due to the intercalation of $C_{8}OH$ and $C_{10}OH$ might induce changes in the activity of integral membrane proteins engaged in neuronal pathways.
536 _ _ |0 G:(DE-H253)POF2-A2-20130405
|f POF II
|x 0
|c POF2-54G13
|a DORIS Beamline A2 (POF2-54G13)
588 _ _ |a Dataset connected to CrossRef, bib-pubdb1.desy.de
693 _ _ |a DORIS III
|f DORIS Beamline A2
|1 EXP:(DE-H253)DORISIII-20150101
|0 EXP:(DE-H253)D-A2-20150101
|6 EXP:(DE-H253)D-A2-20150101
|x 0
700 1 _ |a Karlovská, Janka
|0 P:(DE-H253)PIP1010043
|b 1
700 1 _ |a Uhríková, Daniela
|0 P:(DE-H253)PIP1008450
|b 2
700 1 _ |a Funari, Sergio de Souza
|0 P:(DE-H253)PIP1002601
|b 3
|u desy
700 1 _ |a Balgavý, Pavol
|0 P:(DE-H253)PIP1009344
|b 4
773 _ _ |a 10.1039/C4SM00530A
|g Vol. 10, no. 31, p. 5842 -
|0 PERI:(DE-600)2191476-X
|n 31
|p 5842 - 5848
|t Soft matter
|v 10
|y 2014
|x 1744-6848
856 4 _ |u https://bib-pubdb1.desy.de/record/207189/files/c4sm00530a.pdf
|y Restricted
856 4 _ |u https://bib-pubdb1.desy.de/record/207189/files/c4sm00530a.gif?subformat=icon
|x icon
|y Restricted
856 4 _ |u https://bib-pubdb1.desy.de/record/207189/files/c4sm00530a.jpg?subformat=icon-1440
|x icon-1440
|y Restricted
856 4 _ |u https://bib-pubdb1.desy.de/record/207189/files/c4sm00530a.jpg?subformat=icon-180
|x icon-180
|y Restricted
856 4 _ |u https://bib-pubdb1.desy.de/record/207189/files/c4sm00530a.jpg?subformat=icon-640
|x icon-640
|y Restricted
856 4 _ |u https://bib-pubdb1.desy.de/record/207189/files/c4sm00530a.jpg?subformat=icon-700
|x icon-700
|y Restricted
856 4 _ |u https://bib-pubdb1.desy.de/record/207189/files/c4sm00530a.pdf?subformat=pdfa
|x pdfa
|y Restricted
909 C O |p VDB
|o oai:bib-pubdb1.desy.de:207189
910 1 _ |a Externes Institut
|0 I:(DE-HGF)0
|k >Extern
|b 1
|6 P:(DE-H253)PIP1010043
910 1 _ |a Externes Institut
|0 I:(DE-HGF)0
|k >Extern
|b 2
|6 P:(DE-H253)PIP1008450
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 3
|6 P:(DE-H253)PIP1002601
910 1 _ |a Externes Institut
|0 I:(DE-HGF)0
|k >Extern
|b 4
|6 P:(DE-H253)PIP1009344
913 2 _ |a DE-HGF
|b Forschungsbereich Materie
|l Von Materie zu Materialien und Leben
|1 G:(DE-HGF)POF3-620
|0 G:(DE-HGF)POF3-621
|2 G:(DE-HGF)POF3-600
|v In-house research on the structure, dynamics and function of matter
|9 G:(DE-HGF)POF3-6215
|x 0
913 1 _ |b Struktur der Materie
|1 G:(DE-HGF)POF2-540
|0 G:(DE-HGF)POF2-54G13
|2 G:(DE-HGF)POF2-500
|v DORIS III
|9 G:(DE-H253)POF2-A2-20130405
|x 0
|a DE-H253
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF2
|l Forschung mit Photonen, Neutronen, Ionen
914 1 _ |y 2014
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Thomson Reuters Master Journal List
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a Allianz-Lizenz / DFG
|0 StatID:(DE-HGF)0400
|2 StatID
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
920 1 _ |0 I:(DE-H253)HAS-User-20120731
|k DOOR
|l DOOR-User
|x 0
920 1 _ |0 I:(DE-H253)FS-DO-20120731
|k FS-DO
|l FS-Experimentebetreuung DORIS
|x 1
920 1 _ |0 I:(DE-H253)FS-PEX-20130206
|k FS-PEX
|l PETRA III Extension
|x 2
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-H253)HAS-User-20120731
980 _ _ |a I:(DE-H253)FS-DO-20120731
980 _ _ |a I:(DE-H253)FS-PEX-20130206
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21