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000207189 1001_ $$0P:(DE-HGF)0$$aKlacsová, Mária$$b0$$eCorresponding Author
000207189 245__ $$aPhase Behavior of the DOPE + DOPC + Alkanol System
000207189 260__ $$aLondon$$bRoyal Soc. of Chemistry$$c2014
000207189 3367_ $$00$$2EndNote$$aJournal Article
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000207189 500__ $$a(c) The Royal Society of Chemistry. Post referee full text in progress.
000207189 520__ $$aSmall- and wide-angle X-ray diffraction was used to study the effect of 1-alkanols, as simple models of general anesthetics, (abbreviation $C_{n}OH$, n = 8–18 is the even number of carbons in the aliphatic chain) on the lamellar to hexagonal $L\alpha \rightarrow H_{II}$ phase transition in the dioleoylphosphatidylethanolamine–dioleoylphosphatidylcholine = 3 : 1 mol/mol (DOPE + DOPC) system. All studied $C_{n}OHs$ were found to decrease the phase transition temperature of the DOPE + DOPC system in a $C_{n}OH$ chain length and concentration dependent manner and thus promote the formation of the $H_{II}$ phase. Anesthetically active $C_{8}OH$ and $C_{10}OH$ were found to decrease the lattice parameter $\mathit{d}$ of the $L\alpha$ phase, however longer non-anesthetic CnOHs increased the parameter $\mathit{d}$; this effect being more pronounced with increasing $C_{n}OH$ concentration. The lattice parameter $\mathit{a}$ of the $H_{II}$ phase was decreased in the presence of all $C_{n}OHs$, even at the lowest concentrations studied. In the scope of the indirect mechanism of general anesthesia observed changes in the lattice parameter $\mathit{d}$ (reflecting changes in the bilayer thickness) due to the intercalation of $C_{8}OH$ and $C_{10}OH$ might induce changes in the activity of integral membrane proteins engaged in neuronal pathways.
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000207189 7001_ $$0P:(DE-H253)PIP1010043$$aKarlovská, Janka$$b1
000207189 7001_ $$0P:(DE-H253)PIP1008450$$aUhríková, Daniela$$b2
000207189 7001_ $$0P:(DE-H253)PIP1002601$$aFunari, Sergio de Souza$$b3$$udesy
000207189 7001_ $$0P:(DE-H253)PIP1009344$$aBalgavý, Pavol$$b4
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