Journal Article

PUBDB-2015-00006

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png 4-Amino-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases

Rutkauskas, K. (Corresponding Author) ; Zubrienė, A. ; Tumosienė, I. ; Kantminienė, K. ; Kažemėkaitė, M. ; Smirnov, A.>Extern* ; Kazokaitė, J. ; Morkūnaitė, V. ; Čapkauskaitė, E. ; Manakova, E.>Extern* ; Gražulis, S.>Extern* ; Beresnevičius, Z. ; Matulis, D.

2014
MDPI Basel

This record in other databases:        

Please use a persistent id in citations: doi:10.3390/molecules191117356

Abstract: Abstract: A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containingaliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I,II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay and isothermaltitration calorimetry. The results showed that 4-substituted diazobenzenesulfonamides weremore potent CA binders than N-aryl-β-alanine derivatives. Most of the N-aryl-β-alaninederivatives showed better affinity for CA II while diazobenzenesulfonamides possessednanomolar affinities towards CA I isozyme. X-ray crystallographic structures showed themodes of binding of both compound groups.

Note: OA

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Contributing Institute(s):

1. EMBL-User (EMBL-User)

Research Program(s):

1. PETRA Beamline P13 (POF2-54G14) (POF2-54G14)
2. MOBILI - Strengthening and Sustaining the European Perspectives of Molecular Biotechnology in Lithuania (245721) (245721)

Experiment(s):

1. PETRA Beamline P13 (PETRA III)

Appears in the scientific report 2014

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Database coverage:
; ; ; ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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