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000205429 1001_ $$0P:(DE-HGF)0$$aRutkauskas, Kęstutis$$b0$$eCorresponding Author
000205429 245__ $$a4-Amino-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
000205429 260__ $$aBasel$$bMDPI$$c2014
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000205429 520__ $$aAbstract: A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containingaliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I,II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay and isothermaltitration calorimetry. The results showed that 4-substituted diazobenzenesulfonamides weremore potent CA binders than N-aryl-β-alanine derivatives. Most of the N-aryl-β-alaninederivatives showed better affinity for CA II while diazobenzenesulfonamides possessednanomolar affinities towards CA I isozyme. X-ray crystallographic structures showed themodes of binding of both compound groups.
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000205429 7001_ $$0P:(DE-HGF)0$$aZubrienė, Asta$$b1
000205429 7001_ $$0P:(DE-HGF)0$$aTumosienė, Ingrida$$b2
000205429 7001_ $$0P:(DE-HGF)0$$aKantminienė, Kristina$$b3
000205429 7001_ $$0P:(DE-HGF)0$$aKažemėkaitė, Marytė$$b4
000205429 7001_ $$0P:(DE-H253)PIP1018767$$aSmirnov, Alexey$$b5
000205429 7001_ $$0P:(DE-HGF)0$$aKazokaitė, Justina$$b6
000205429 7001_ $$0P:(DE-HGF)0$$aMorkūnaitė, Vaida$$b7
000205429 7001_ $$0P:(DE-HGF)0$$aČapkauskaitė, Edita$$b8
000205429 7001_ $$0P:(DE-H253)PIP1017370$$aManakova, Elena$$b9
000205429 7001_ $$0P:(DE-H253)PIP1018629$$aGražulis, Saulius$$b10
000205429 7001_ $$0P:(DE-HGF)0$$aBeresnevičius, Zigmuntas$$b11
000205429 7001_ $$0P:(DE-HGF)0$$aMatulis, Daumantas$$b12
000205429 773__ $$0PERI:(DE-600)2008644-1$$a10.3390/molecules191117356$$gVol. 19, no. 11, p. 17356 - 17380$$n11$$p17356 - 17380$$tMolecules$$v19$$x1420-3049$$y2014
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