Journal Article

PUBDB-2026-01130

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Extending the Field of View in Modulation-Based X-Ray Phase Microtomography

John, D. (Corresponding author)Extern*Hereon* ; Chen, J.Extern* ; Gaßner, C.Extern* ; Savatović, S.Extern* ; Petzold, L. M.Extern* ; Wirtensohn, S.Extern*Hereon* ; Riedel, M.Extern*HZG*Hereon* ; Hammel, J. U.HZG*Hereon* ; Moosmann, J.HZG*Hereon* ; Beckmann, F.HZG*Hereon* ; Wieczorek, M. ; Herzen, J.Extern*

2026
IEEE New York, NY

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Please use a persistent id in citations: doi:10.1109/TIP.2026.3676631  doi:10.3204/PUBDB-2026-01130

Abstract: Recent advances in propagation-based phase-contrast imaging, such as hierarchical imaging, have enabled the visualization of internal structures in large biological specimens and material samples. However, modulation-based techniques, which provide quantitative electron density information, face challenges when imaging larger objects due to stringent beam stability requirements and detector distortions. Extending the field of view of these methods is crucial for obtaining comparable quantitative results across beamlines and adapting to the smaller beam profiles of fourth-generation synchrotron sources. We introduce a novel image processing technique combining an eigenflat optimization with deformable image registration to address the challenges and enable quantitative high-resolution scans of centimeter-sized objects with multiple-micrometer resolution. We demonstrate the potential of the method by obtaining an electron density map of a rat brain sample 15mm in diameter despite the limited horizontal field of view of 6mm of the beamline. This showcases the technique’s ability to significantly widen the range of applications of modulation-based techniques in both biological and materials science research.

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)
2. Helmholtz-Zentrum Hereon (Hereon)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)

Experiment(s):

1. PETRA Beamline P05 (PETRA III)

Appears in the scientific report 2026

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Engineering, Computing and Technology ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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