Journal Article

PUBDB-2025-05609

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Two residues reprogram immunity receptors for nitrogen-fixing symbiosis

Tsitsikli, M. ; Simonsen, B. ; Luu, T.-B. ; Larsen, M. M. ; Andersen, C. G. ; Gysel, K. ; Lironi, D. ; Krönauer, C. ; Rübsam, H. ; Hansen, S. B. ; Bærentsen, R. ; Wulff, J. L. ; Johansen, S. H. ; Sezer, G. ; Stougaard, J. ; Andersen, K. (Corresponding author)Extern* ; Radutoiu, S. (Corresponding author)

2025
Nature Publ. Group London [u.a.]

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Please use a persistent id in citations: doi:10.1038/s41586-025-09696-3

Abstract: Receptor signalling determines cellular responses and is crucial for defining specific biological outcomes. In legume root cells, highly similar and structurally conserved chitin and Nod factor receptor kinases activate immune or symbiotic pathways, respectively, when chitinous ligands are perceived1. Here we show that specific amino acid residues in the intracellular part of the Nod factor receptor NFR1 control signalling specificity and enable the distinction of immune and symbiotic responses. Functional investigation of CERK6, NFR1 and receptor variants thereof revealed a conserved motif that we term Symbiosis Determinant 1 in the juxtamembrane region of the kinase domain, which is key for symbiotic signalling. We show that two residues in Symbiosis Determinant 1 are indispensable hallmarks of NFR1-type receptors and are sufficient to convert Lotus CERK6 and barley RLK4 kinase outputs to enable symbiotic signalling in Lotus japonicus.

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Contributing Institute(s):

1. EMBL-User (EMBL-User)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)

Experiment(s):

1. PETRA Beamline P13 (PETRA III)

Appears in the scientific report 2025

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