000642760 001__ 642760
000642760 005__ 20251218212323.0
000642760 0247_ $$2doi$$a10.1038/s41586-025-09696-3
000642760 0247_ $$2ISSN$$a0028-0836
000642760 0247_ $$2ISSN$$a1476-4687
000642760 037__ $$aPUBDB-2025-05609
000642760 041__ $$aEnglish
000642760 082__ $$a500
000642760 1001_ $$00009-0008-8753-529X$$aTsitsikli, Magdalini$$b0
000642760 245__ $$aTwo residues reprogram immunity receptors for nitrogen-fixing symbiosis
000642760 260__ $$aLondon [u.a.]$$bNature Publ. Group$$c2025
000642760 3367_ $$2DRIVER$$aarticle
000642760 3367_ $$2DataCite$$aOutput Types/Journal article
000642760 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1766067794_1297607
000642760 3367_ $$2BibTeX$$aARTICLE
000642760 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000642760 3367_ $$00$$2EndNote$$aJournal Article
000642760 500__ $$aWaiting for fulltext 
000642760 520__ $$aReceptor signalling determines cellular responses and is crucial for defining specific biological outcomes. In legume root cells, highly similar and structurally conserved chitin and Nod factor receptor kinases activate immune or symbiotic pathways, respectively, when chitinous ligands are perceived1. Here we show that specific amino acid residues in the intracellular part of the Nod factor receptor NFR1 control signalling specificity and enable the distinction of immune and symbiotic responses. Functional investigation of CERK6, NFR1 and receptor variants thereof revealed a conserved motif that we term Symbiosis Determinant 1 in the juxtamembrane region of the kinase domain, which is key for symbiotic signalling. We show that two residues in Symbiosis Determinant 1 are indispensable hallmarks of NFR1-type receptors and are sufficient to convert Lotus CERK6 and barley RLK4 kinase outputs to enable symbiotic signalling in Lotus japonicus.
000642760 536__ $$0G:(DE-HGF)POF4-6G3$$a6G3 - PETRA III (DESY) (POF4-6G3)$$cPOF4-6G3$$fPOF IV$$x0
000642760 588__ $$aDataset connected to CrossRef, Journals: bib-pubdb1.desy.de
000642760 693__ $$0EXP:(DE-H253)P-P13-20150101$$1EXP:(DE-H253)PETRAIII-20150101$$6EXP:(DE-H253)P-P13-20150101$$aPETRA III$$fPETRA Beamline P13$$x0
000642760 7001_ $$0P:(DE-HGF)0$$aSimonsen, Bine$$b1
000642760 7001_ $$00000-0001-8148-6927$$aLuu, Thi-Bich$$b2
000642760 7001_ $$aLarsen, Maria M.$$b3
000642760 7001_ $$aAndersen, Camilla G.$$b4
000642760 7001_ $$0P:(DE-HGF)0$$aGysel, Kira$$b5
000642760 7001_ $$aLironi, Damiano$$b6
000642760 7001_ $$aKrönauer, Christina$$b7
000642760 7001_ $$aRübsam, Henriette$$b8
000642760 7001_ $$00000-0002-0843-3922$$aHansen, Simon B.$$b9
000642760 7001_ $$aBærentsen, René$$b10
000642760 7001_ $$aWulff, Jesper Lundsgaard$$b11
000642760 7001_ $$aJohansen, Sarah Holt$$b12
000642760 7001_ $$aSezer, Gülendam$$b13
000642760 7001_ $$0P:(DE-HGF)0$$aStougaard, Jens$$b14
000642760 7001_ $$0P:(DE-H253)PIP1087231$$aAndersen, Kasper$$b15$$eCorresponding author
000642760 7001_ $$0P:(DE-HGF)0$$aRadutoiu, Simona$$b16$$eCorresponding author
000642760 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/s41586-025-09696-3$$gVol. 648, no. 8093, p. 443 - 450$$n8093$$p443 - 450$$tNature$$v648$$x0028-0836$$y2025
000642760 8564_ $$uhttps://www.nature.com/articles/s41586-025-09696-3#data-availability
000642760 8564_ $$uhttps://bib-pubdb1.desy.de/record/642760/files/Two%20residues%20reprogram%20immunity%20receptors%20for%20nitrogen-fixing%20symbiosis.pdf$$yRestricted
000642760 8564_ $$uhttps://bib-pubdb1.desy.de/record/642760/files/Two%20residues%20reprogram%20immunity%20receptors%20for%20nitrogen-fixing%20symbiosis.pdf?subformat=pdfa$$xpdfa$$yRestricted
000642760 909CO $$ooai:bib-pubdb1.desy.de:642760$$pVDB
000642760 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1087231$$aExternal Institute$$b15$$kExtern
000642760 9131_ $$0G:(DE-HGF)POF4-6G3$$1G:(DE-HGF)POF4-6G0$$2G:(DE-HGF)POF4-600$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bForschungsbereich Materie$$lGroßgeräte: Materie$$vPETRA III (DESY)$$x0
000642760 9141_ $$y2025
000642760 915__ $$0StatID:(DE-HGF)3003$$2StatID$$aDEAL Nature$$d2025-01-06$$wger
000642760 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)1200$$2StatID$$aDBCoverage$$bChemical Reactions$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)1210$$2StatID$$aDBCoverage$$bIndex Chemicus$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNATURE : 2022$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2025-01-06
000642760 915__ $$0StatID:(DE-HGF)9960$$2StatID$$aIF >= 60$$bNATURE : 2022$$d2025-01-06
000642760 9201_ $$0I:(DE-H253)EMBL-User-20120814$$kEMBL-User$$lEMBL-User$$x0
000642760 980__ $$ajournal
000642760 980__ $$aVDB
000642760 980__ $$aI:(DE-H253)EMBL-User-20120814
000642760 980__ $$aUNRESTRICTED