Journal Article

PUBDB-2025-04447

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png New twists in anti-malarial drug resistance

Cubillán-Marín, J. ; Gilberger, T. W. (Corresponding author)CSSB*

2025
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.chembiol.2025.09.009

Abstract: n this issue of Cell Chemical Biology, Bopp et al.1 discover that malaria parasite resistance to halofuginone is mediated by mutations in PfApiAT2, an amino acid transporter, rather than halofuginone’s target prolyl-tRNA synthetase. This rapid and distinctive resistance mechanism highlights amino acid transport as a promising avenue for drug discovery.

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Contributing Institute(s):

1. CSSB-BNITM-TG (CSSB-BNITM-TG)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Experiment(s):

1. No specific instrument

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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