Journal Article

PUBDB-2025-03800

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Biodistribution of nanoplastics in mice: advancing analytical techniques using metal-doped plastics

Staufer, T. (Corresponding author)Extern* ; Kopatz, V. (Corresponding author) ; Pradel, A. ; Brodie, T. ; Kuhrwahl, R.Extern* ; Stroka, D. ; Wallner, J. ; Kenner, L. (Corresponding author) ; Pichler, V. ; Grüner, F.CFEL*Extern* ; Mitrano, D. M.

2025
Springer Nature London

This record in other databases:  

Please use a persistent id in citations: doi:10.1038/s42003-025-08709-1  doi:10.3204/PUBDB-2025-03800

Abstract: Contamination of plastic particles in environmental and biological systems raises concerns regarding their potential negative impacts. Human exposure to microplastics (MPs) and nanoplastics (NPs) is increasing; however, some potential adverse health effects might remain unclear, due to analytical challenges in detecting trace concentrations. To address this, we propose a workflow for NPs assessment in biological samples combining three complimentary methods, namely inductively coupled plasma mass spectrometry (ICP-MS), X-ray fluorescence imaging (XFI), and imaging mass cytometry (IMC) to detect palladium-doped NPs (Pd-NPs). This approach was used to quantify the temporal distribution and accumulation of Pd-NPs in mouse models under different experimental conditions, dosages, and time frames. Acute exposure showed a clear particle excretion from the gastrointestinal tract into feces, while subchronic exposure led to tissue accumulation. This workflow enhances our ability to analyze and study NP uptake and biodistribution mechanisms down to the nanoscale in complex biological samples.

---

Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
2. SENSE - Structure and Ecological Niche in the Soil Environment (631399) (631399)

Experiment(s):

1. PETRA Beamline P21.1 (PETRA III)

Appears in the scientific report 2025

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

---