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@ARTICLE{Staufer:637191,
      author       = {Staufer, Theresa and Kopatz, Verena and Pradel, Alice and
                      Brodie, Tess and Kuhrwahl, Robert and Stroka, Deborah and
                      Wallner, Julia and Kenner, Lukas and Pichler, Verena and
                      Grüner, Florian and Mitrano, Denise M.},
      title        = {{B}iodistribution of nanoplastics in mice: advancing
                      analytical techniques using metal-doped plastics},
      journal      = {Communications biology},
      volume       = {8},
      number       = {1},
      issn         = {2399-3642},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {PUBDB-2025-03800},
      pages        = {1247},
      year         = {2025},
      abstract     = {Contamination of plastic particles in environmental and
                      biological systems raises concerns regarding their potential
                      negative impacts. Human exposure to microplastics (MPs) and
                      nanoplastics (NPs) is increasing; however, some potential
                      adverse health effects might remain unclear, due to
                      analytical challenges in detecting trace concentrations. To
                      address this, we propose a workflow for NPs assessment in
                      biological samples combining three complimentary methods,
                      namely inductively coupled plasma mass spectrometry
                      (ICP-MS), X-ray fluorescence imaging (XFI), and imaging mass
                      cytometry (IMC) to detect palladium-doped NPs (Pd-NPs). This
                      approach was used to quantify the temporal distribution and
                      accumulation of Pd-NPs in mouse models under different
                      experimental conditions, dosages, and time frames. Acute
                      exposure showed a clear particle excretion from the
                      gastrointestinal tract into feces, while subchronic exposure
                      led to tissue accumulation. This workflow enhances our
                      ability to analyze and study NP uptake and biodistribution
                      mechanisms down to the nanoscale in complex biological
                      samples.},
      cin          = {DOOR ; HAS-User / CFEL-NOVA},
      ddc          = {570},
      cid          = {I:(DE-H253)HAS-User-20120731 /
                      I:(DE-H253)CFEL-NOVA-20160909},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3) / SENSE - Structure and
                      Ecological Niche in the Soil Environment (631399)},
      pid          = {G:(DE-HGF)POF4-6G3 / G:(EU-Grant)631399},
      experiment   = {EXP:(DE-H253)P-P21.1-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40830574},
      doi          = {10.1038/s42003-025-08709-1},
      url          = {https://bib-pubdb1.desy.de/record/637191},
}