Journal Article

PUBDB-2025-01085

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png High-Pressure Polymorphism of Ribavirin

Tiwari, B.Extern*DESY* ; Liermann, H.-P.DESY* ; Parsons, S. (Corresponding author)Extern* ; Giordano, N. (Corresponding author)DESY*

2025
ACS Publ. Washington, DC

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Please use a persistent id in citations: doi:10.1021/acs.cgd.5c00372  doi:10.3204/PUBDB-2025-01085

Abstract: The effect of high pressure on ribavirin, a broad-spectrum antiviral consisting of ribofuranosyl triazole, and carboxamide moieties, has been studied up to ~10 GPa. Three new high-pressure phases, designated V3, V4 and V5, have been obtained by compression of the ambient-pressure V2 form with structures refined up to 7.5 GPa. The new phases are formed at 5.3 GPa, 6.0 GPa, and 7.2 GPa, respectively, and crystallize in space group P212121 with Z’ = 3, 1 and 1. They are distinguished by changes in the conformation of the ribofuranosyl moiety which impacts both the molecular geometry and the supramolecular structure.

Note: The DESY Strategy Fund (DSF) and Engineering and Physical Sciences Research Council (EPSRC, UK) provided studentship funding for BT. EPSRC also provided funding for instrumentation (grant No. EP/R042845/1)

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)
2. PETRA-D (FS-PETRA-D)

Research Program(s):

1. 631 - Matter – Dynamics, Mechanisms and Control (POF4-631) (POF4-631)
2. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
3. FS-Proposal: I-20211310 (I-20211310) (I-20211310)
4. FS-Proposal: I-20220306 (I-20220306) (I-20220306)

Experiment(s):

1. PETRA Beamline P02.2 (PETRA III)

Appears in the scientific report 2025

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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