%0 Journal Article
%A Tiwari, Bhaskar
%A Liermann, Hanns-Peter
%A Parsons, Simon
%A Giordano, Nico
%T High-Pressure Polymorphism of Ribavirin 
%J Crystal growth & design
%V 25
%N 10
%@ 1528-7483
%C Washington, DC
%I ACS Publ.
%M PUBDB-2025-01085
%P 3537 - 3547
%D 2025
%Z The DESY Strategy Fund (DSF) and Engineering and Physical Sciences Research Council (EPSRC, UK) provided studentship funding for BT. EPSRC also provided funding for instrumentation (grant No. EP/R042845/1)
%X The effect of high pressure on ribavirin, a broad-spectrum antiviral consisting of ribofuranosyl triazole, and carboxamide moieties, has been studied up to  10 GPa. Three new high-pressure phases, designated V3, V4 and V5, have been obtained by compression of the ambient-pressure V2 form with structures refined up to 7.5 GPa. The new phases are formed at 5.3 GPa, 6.0 GPa, and 7.2 GPa, respectively, and crystallize in space group P212121 with Z’ = 3, 1 and 1. They are distinguished by changes in the conformation of the ribofuranosyl moiety which impacts both the molecular geometry and the supramolecular structure.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 40417264
%U <Go to ISI:>//WOS:001485833200001
%R 10.1021/acs.cgd.5c00372
%U https://bib-pubdb1.desy.de/record/625297