Journal Article

PUBDB-2024-06360

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Photoinduced bidirectional mesophase transition in vesicles containing azobenzene amphiphiles

Hövelmann, S. C.Extern* ; Dieball, E.Extern*EMBL* ; Kuhn, J.Extern* ; Dargasz, M.Extern*XFEL.EU* ; Giri, R. P.Extern* ; Reise, F. ; Paulus, M.Extern* ; Lindhorst, T. K. ; Murphy, B. M. (Corresponding author)Extern*XFEL.EU*DESY*

2024
IUCr Chester

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Please use a persistent id in citations: doi:10.1107/S2052252524004032  doi:10.3204/PUBDB-2024-06360

Abstract: The functionality and efficiency of proteins within a biological membrane are highly dependent on both the membrane lipid composition and the physiochemical properties of the solution. Lipid mesophases are directly influenced by changes in temperature, pH, water content or due to individual properties of single lipids such as photoswitchability. In this work, we were able to induce light- and temperature-driven mesophase transitions in a model membrane system containing a mixture of 1,2-dipalmitoyl-phosphatidylcholine phospho­lipids and azo­benzene amphiphiles. We observed reversible and reproducible transitions between the lamellar and Pn3m cubic phase after illuminating the sample for 5 min with light of 365 and 455 nm wavelengths, respectively, to switch between the cis and trans states of the azo­benzene N=N double bond. These light-controlled mesophase transitions were found for mixed complexes with up to 20% content of the photosensitive molecule and at temperatures below the gel-to-liquid crystalline phase transition temperature of 33°C. Our results demonstrate the potential to design bespoke model systems to study the response of membrane lipids and proteins upon changes in mesophase without altering the environment and thus provide a possible basis for drug delivery systems.

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)
2. Spectroscopy of molecular processes (FS-SMP)

Research Program(s):

1. 631 - Matter – Dynamics, Mechanisms and Control (POF4-631) (POF4-631)
2. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
3. DFG project G:(GEPRIS)460248799 - DAPHNE4NFDI - DAten aus PHoton- und Neutronen Experimenten für NFDI (460248799) (460248799)

Experiment(s):

1. PETRA Beamline P08 (PETRA III)

Appears in the scientific report 2024

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