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@ARTICLE{Hvelmann:616200,
author = {Hövelmann, Svenja C. and Dieball, Ella and Kuhn, Jule and
Dargasz, Michelle and Giri, Rajendra P. and Reise, Franziska
and Paulus, Michael and Lindhorst, Thisbe K. and Murphy,
Bridget M.},
title = {{P}hotoinduced bidirectional mesophase transition in
vesicles containing azobenzene amphiphiles},
journal = {IUCrJ},
volume = {11},
number = {4},
issn = {2052-2525},
address = {Chester},
publisher = {IUCr},
reportid = {PUBDB-2024-06360},
pages = {486-493},
year = {2024},
abstract = {The functionality and efficiency of proteins within a
biological membrane are highly dependent on both the
membrane lipid composition and the physiochemical properties
of the solution. Lipid mesophases are directly influenced by
changes in temperature, pH, water content or due to
individual properties of single lipids such as
photoswitchability. In this work, we were able to induce
light- and temperature-driven mesophase transitions in a
model membrane system containing a mixture of
1,2-dipalmitoyl-phosphatidylcholine phospholipids and
azobenzene amphiphiles. We observed reversible and
reproducible transitions between the lamellar and Pn3m cubic
phase after illuminating the sample for 5 min with light
of 365 and 455 nm wavelengths, respectively, to switch
between the cis and trans states of the azobenzene N=N
double bond. These light-controlled mesophase transitions
were found for mixed complexes with up to $20\%$ content of
the photosensitive molecule and at temperatures below the
gel-to-liquid crystalline phase transition temperature of
33°C. Our results demonstrate the potential to design
bespoke model systems to study the response of membrane
lipids and proteins upon changes in mesophase without
altering the environment and thus provide a possible basis
for drug delivery systems.},
cin = {DOOR ; HAS-User / FS-SMP},
ddc = {530},
cid = {I:(DE-H253)HAS-User-20120731 / I:(DE-H253)FS-SMP-20171124},
pnm = {631 - Matter – Dynamics, Mechanisms and Control
(POF4-631) / 6G3 - PETRA III (DESY) (POF4-6G3) / DFG project
G:(GEPRIS)460248799 - DAPHNE4NFDI - DAten aus PHoton- und
Neutronen Experimenten für NFDI (460248799)},
pid = {G:(DE-HGF)POF4-631 / G:(DE-HGF)POF4-6G3 /
G:(GEPRIS)460248799},
experiment = {EXP:(DE-H253)P-P08-20150101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:38805319},
UT = {WOS:001273030200009},
doi = {10.1107/S2052252524004032},
url = {https://bib-pubdb1.desy.de/record/616200},
}