Journal Article

PUBDB-2023-03635

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Laser-induced alignment of nanoparticles and macromolecules for single-particle-imaging applications

Amin, M.CFEL*Extern* ; Hartmann, J.-M. ; Samanta, A. K.CFEL*XFEL.EU*DESY* ; Küpper, J. (Corresponding author)CFEL*XFEL.EU*DESY*

2025
ACS Publications Washington, DC

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Please use a persistent id in citations: doi:10.1021/jacs.4c15679  doi:10.3204/PUBDB-2023-03635

Abstract: Laser-induced alignment of particles and molecules was long envisioned to support three-dimensional structure determination using “single-molecule diffraction” with X-ray free-electron lasers [PRL 92, 198102 (2004)]. However, the alignment of isolated macromolecules has not yet been demonstrated also because quantitative modeling is very expensive. We computationally demonstrated that the alignment of nanorods and proteins is possible with a standard laser technology. We performed a comprehensive analysis on the dependence of the degree of alignment on molecular properties and experimental details, e.g., particle temperature and laser-pulse energy. Considering the polarizability anisotropy of about 150,000 proteins, our analysis revealed that most of these proteins can be aligned using realistic experimental parameters.

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Contributing Institute(s):

1. CFEL-CMI (FS-CFEL-CMI)
2. Uni Hamburg / Experimentalphysik (UNI/EXP)
3. beauftragt von UNI (UNI/CUI)

Research Program(s):

1. 631 - Matter – Dynamics, Mechanisms and Control (POF4-631) (POF4-631)
2. AIM, DFG project G:(GEPRIS)390715994 - EXC 2056: CUI: Advanced Imaging of Matter (390715994) (390715994)
3. COMOTION - Controlling the Motion of Complex Molecules and Particles (614507) (614507)

Experiment(s):

1. No specific instrument

Appears in the scientific report 2025

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Electronics and Telecommunications Collection ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; IF >= 5 ; Index Chemicus ; JCR ; Nationallizenz ; SCOAP3 sponsored Journal ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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