%0 Journal Article
%A Amin, Muhamed
%A Hartmann, J-M
%A Samanta, Amit Kumar
%A Küpper, Jochen
%T Laser-induced alignment of nanoparticles and macromolecules for single-particle-imaging applications
%J Journal of the American Chemical Society
%V 147
%N 9
%@ 0002-7863
%C Washington, DC
%I ACS Publications
%M PUBDB-2023-03635
%P 7445 - 7451
%D 2025
%X Laser-induced alignment of particles and molecules was long envisioned to support three-dimensional structure determination using “single-molecule diffraction” with X-ray free-electron lasers [PRL 92, 198102 (2004)]. However, the alignment of isolated macromolecules has not yet been demonstrated also because quantitative modeling is very expensive. We computationally demonstrated that the alignment of nanorods and proteins is possible with a standard laser technology. We performed a comprehensive analysis on the dependence of the degree of alignment on molecular properties and experimental details, e.g., particle temperature and laser-pulse energy. Considering the polarizability anisotropy of about 150,000 proteins, our analysis revealed that most of these proteins can be aligned using realistic experimental parameters.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39900544
%U <Go to ISI:>//WOS:001413255700001
%R 10.1021/jacs.4c15679
%U https://bib-pubdb1.desy.de/record/585553