Journal Article PUBDB-2023-03635

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Laser-induced alignment of nanoparticles and macromolecules for single-particle-imaging applications

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2025
ACS Publications Washington, DC

Journal of the American Chemical Society 147(9), 7445 - 7451 () [10.1021/jacs.4c15679]
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Abstract: Laser-induced alignment of particles and molecules was long envisioned to support three-dimensional structure determination using “single-molecule diffraction” with X-ray free-electron lasers [PRL 92, 198102 (2004)]. However, the alignment of isolated macromolecules has not yet been demonstrated also because quantitative modeling is very expensive. We computationally demonstrated that the alignment of nanorods and proteins is possible with a standard laser technology. We performed a comprehensive analysis on the dependence of the degree of alignment on molecular properties and experimental details, e.g., particle temperature and laser-pulse energy. Considering the polarizability anisotropy of about 150,000 proteins, our analysis revealed that most of these proteins can be aligned using realistic experimental parameters.

Classification:

Contributing Institute(s):
  1. CFEL-CMI (FS-CFEL-CMI)
  2. Uni Hamburg / Experimentalphysik (UNI/EXP)
  3. beauftragt von UNI (UNI/CUI)
Research Program(s):
  1. 631 - Matter – Dynamics, Mechanisms and Control (POF4-631) (POF4-631)
  2. AIM, DFG project G:(GEPRIS)390715994 - EXC 2056: CUI: Advanced Imaging of Matter (390715994) (390715994)
  3. COMOTION - Controlling the Motion of Complex Molecules and Particles (614507) (614507)
Experiment(s):
  1. No specific instrument

Appears in the scientific report 2025
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 Record created 2023-06-05, last modified 2025-07-15


Published on 2025-02-03. Available in OpenAccess from 2026-02-03.:
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