Cerosomes as skin repairing agent: Mode of action studies with a modelstratum corneum layer at liquid/air and liquid/solid interfaces

Strati, Fabio; Schmelzer, Christian E. H.; Neubert, Reinhard H. H.; Hause, Gerd; Mukhina, Tetiana; Brezesinski, Gerald; Menzel, Matthias; Opalka, Lukas

doi:10.1016/j.bbadva.2021.100039

Journal Article

PUBDB-2022-07133

Cerosomes as skin repairing agent: Mode of action studies with a modelstratum corneum layer at liquid/air and liquid/solid interfaces

Strati, F. ; Mukhina, T. ; Neubert, R. H. H. ; Opalka, L. ; Hause, G. ; Schmelzer, C. E. H. ; Menzel, M. ; Brezesinski, G. (Corresponding author)Extern*

2022
Elsevier [Amsterdam]

BBA advances 2, 100039 (2022) [10.1016/j.bbadva.2021.100039]

This record in other databases:

Please use a persistent id in citations: doi:10.1016/j.bbadva.2021.100039 doi:10.3204/PUBDB-2022-07133

Abstract: The stratum corneum (SC) is the largest physical barrier of the human body. It protects against physical, chemicaland biological damages, and avoids evaporation of water from the deepest skin layers. For its correct functioning,the homeostasis of the SC lipid matrix is fundamental. An alteration of the lipid matrix composition and inparticular of its ceramide (CER) fraction can lead to the development of pathologies such as atopic dermatitis andpsoriasis. Different studies showed that the direct replenishment of SC lipids on damaged skin had positive effectson the recovery of its barrier properties.In this work, cerosomes, i.e. liposomes composed of SC lipids, have been successfully prepared in order toinvestigate the mechanism of interaction with a model SC lipid matrix. The cerosomes contain CER[NP], D-CER[AP], stearic acid and cholesterol. In addition, hydrogenated soybean phospholipids have been added to one ofthe formulations leading to an increased stability at neutral pH. For the mode of action studies, monolayermodels at the air-water interface and on solid support have been deployed. The results indicated that a stronginteraction occurred between SC monolayers and the cerosomes. Since both systems were negatively charged, thedriving force for the interaction must be based on the ability of CERs head groups to establish intermolecularhydrogen bonding networks that energetically prevailed against the electrostatic repulsion. This work proved forthe first time the mode of action by which cerosomes exploit their function as skin barrier repairing agents on theSC.

Classification: