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@ARTICLE{Strati:486141,
      author       = {Strati, Fabio and Mukhina, Tetiana and Neubert, Reinhard H.
                      H. and Opalka, Lukas and Hause, Gerd and Schmelzer,
                      Christian E. H. and Menzel, Matthias and Brezesinski,
                      Gerald},
      title        = {{C}erosomes as skin repairing agent: {M}ode of action
                      studies with a modelstratum corneum layer at liquid/air and
                      liquid/solid interfaces},
      journal      = {BBA advances},
      volume       = {2},
      issn         = {2667-1603},
      address      = {[Amsterdam]},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2022-07133},
      pages        = {100039},
      year         = {2022},
      abstract     = {The stratum corneum (SC) is the largest physical barrier of
                      the human body. It protects against physical, chemicaland
                      biological damages, and avoids evaporation of water from the
                      deepest skin layers. For its correct functioning,the
                      homeostasis of the SC lipid matrix is fundamental. An
                      alteration of the lipid matrix composition and inparticular
                      of its ceramide (CER) fraction can lead to the development
                      of pathologies such as atopic dermatitis andpsoriasis.
                      Different studies showed that the direct replenishment of SC
                      lipids on damaged skin had positive effectson the recovery
                      of its barrier properties.In this work, cerosomes, i.e.
                      liposomes composed of SC lipids, have been successfully
                      prepared in order toinvestigate the mechanism of interaction
                      with a model SC lipid matrix. The cerosomes contain CER[NP],
                      D-CER[AP], stearic acid and cholesterol. In addition,
                      hydrogenated soybean phospholipids have been added to one
                      ofthe formulations leading to an increased stability at
                      neutral pH. For the mode of action studies, monolayermodels
                      at the air-water interface and on solid support have been
                      deployed. The results indicated that a stronginteraction
                      occurred between SC monolayers and the cerosomes. Since both
                      systems were negatively charged, thedriving force for the
                      interaction must be based on the ability of CERs head groups
                      to establish intermolecularhydrogen bonding networks that
                      energetically prevailed against the electrostatic repulsion.
                      This work proved forthe first time the mode of action by
                      which cerosomes exploit their function as skin barrier
                      repairing agents on theSC.},
      cin          = {DOOR ; HAS-User},
      ddc          = {610},
      cid          = {I:(DE-H253)HAS-User-20120731},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3) / FS-Proposal: I-20190800
                      (I-20190800)},
      pid          = {G:(DE-HGF)POF4-6G3 / G:(DE-H253)I-20190800},
      experiment   = {EXP:(DE-H253)P-P08-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37082599},
      UT           = {WOS:001223528800001},
      doi          = {10.1016/j.bbadva.2021.100039},
      url          = {https://bib-pubdb1.desy.de/record/486141},
}