Journal Article

PUBDB-2018-02981

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tunable, Ultrafast Fiber-Laser Between 1.15 and 1.35 $\mu$m for Harmonic Generation Microscopy in Human Skin

Chung, H.-Y. (Corresponding author)CFEL*Extern*DESY* ; Cao, Q.CFEL*DESY* ; Greinert, R. ; Kartner, F. X.CFEL*Extern*DESY* ; Chang, G.CFEL*DESY* ; Liu, W.

2018
IEEE New York, NY

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Please use a persistent id in citations: doi:10.1109/JSTQE.2018.2864193  doi:10.3204/PUBDB-2018-02981

Abstract: We demonstrate a fiber-optic ultrafast tunable source for harmonic generation microscopy (HGM) in human skin. The source is based on a 31-MHz Er-fiber laser followed byself-phase modulation enabled spectral selection (SESS). The resulting pulses are tunable between 1.15 and 1.35 μm with up to >10-nJ pulse energy and ∼100-fs pulse duration. We employ this source to drive a scanning microscope for HGM imaging of ex vivo human skin. A systematic investigation on imaging depth versus excitation wavelength reveals that excitation wavelengths in the 1.15–1.25 μm range exhibit low optical attenuation within the tissue and allows larger imaging depth for HGM in human skin.HGM driven by fiber-based SESS sources constitutes an enabling tool for noninvasive virtual skin biopsy in clinical applications.

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Contributing Institute(s):

1. FS-CFEL-2 (CFEL-ULOCM)
2. Ultrafast Lasers & X-rays Division (FS-CFEL-2)

Research Program(s):

1. 6211 - Extreme States of Matter: From Cold Ions to Hot Plasmas (POF3-621) (POF3-621)

Experiment(s):

1. No specific instrument

Appears in the scientific report 2018

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Database coverage:
; ; ; Current Contents - Engineering, Computing and Technology ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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