Journal Article

PUBDB-2017-01377

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Energetic Ultrafast Fiber Laser Scources Tunable in 1030-1215 nm for Deep Tissue Multi-Photon Microscopy

Liu, W.CFEL*DESY* ; Chang, G. N. (Corresponding author)CFEL*DESY* ; Chia, S.-H.CFEL*Extern*DESY* ; Chung, H.-Y.CFEL*DESY* ; Kärtner, F.CFEL*Extern*DESY* ; Greinert, R.

2017
OSA Washington, DC

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Please use a persistent id in citations: doi:10.1364/OE.25.006822  doi:10.3204/PUBDB-2017-01377

Abstract: We demonstrate an energy scalable approach to implement ultrafast fiber laser sources suitable for deep tissue multi-photon microscopy imaging. Enabled by fiber-opticnonlinearities (dominated by self-phase modulation), these unique ultrafast sources produce nearly transform-limited pulses of 50-90 fs in duration with the center wavelength tunable inthe wavelength range of 1030-1215 nm. The resulting pulse energy can be scaled up to 20 nJ by optimizing fiber dispersion, shortening fiber length, and using large-mode-area fibers. Weapplied such an energetic source to a proof-of-principle study of ex vivo human skin based on harmonics (i.e., second-harmonic generation and third-harmonic generation) imaging. Thisnew type of fiber-format energetic ultrafast source provides a robust solution for multiphoton microscopy applications.

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Contributing Institute(s):

1. Ultrafast Lasers & X-rays Division (FS-CFEL-2)
2. FS-CFEL-2 (CFEL-ULOCM)
3. FS-CFEL-2 (CFEL-UFOX)
4. beauftragt von UNI (UNI/CUI)

Research Program(s):

1. 6211 - Extreme States of Matter: From Cold Ions to Hot Plasmas (POF3-621) (POF3-621)
2. VH-NG-804 - Towards Laboratory-Based Ultrafast Bright EUV and X-ray Sources (2015_IVF-VH-NG-804) (2015_IVF-VH-NG-804)
3. HCJRG-201 - Advanced Laser Technologies for Ultrafast Spectroscopy of Quantum Materials (2015_IFV-HCJRG-201) (2015_IFV-HCJRG-201)
4. CUI - Hamburger Zentrum für ultraschnelle Beobachtung (194651731) (194651731)

Experiment(s):

1. Experiments at CFEL

Appears in the scientific report 2017

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Database coverage:
; ; ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Free to read ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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