Journal Article

PUBDB-2016-02672

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png On the Adsorption of Magnetite Nanoparticles on Lysozyme Amyloid Fibrils

Majorosova, J.Extern* ; Petrenko, V. I. (Corresponding author) ; Siposova, K. ; Timko, M. ; Tomasovicova, N. ; Garamus, V. M. ; Koralewski, M. ; Avdeev, M. ; Leszczynski, B. ; Jurga, S. ; Gazova, Z. ; Hayryan, S. ; Hu, C.-K. ; Kopcansky, P.

2016
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.colsurfb.2016.07.024

Abstract: An adsorption of magnetic nanoparticles (MNP) from electrostatically stabilized aqueous ferrofluids on amyloid fibrils of hen egg white lysozyme (HEWL) in 2 mg/mL acidic dispersions have been detected for the MNP concentration range of 0.01–0.1 vol.%. The association of the MNP with amyloid fibrils has been characterized by transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS) and magneto-optical measurements. It has been observed that the extent of adsorption is determined by the MNP concentration. When increasing the MNP concentration the formed aggregates of magnetic particles repeat the general rod-like structure of the fibrils. The effect is not observed when MNP are mixed with the solution of lysozyme monomers. The adsorption has been investigated with the aim to clarify previously found disaggregation activity of MNP in amyloid fibrils dispersions and to get deeper insight into interaction processes between amyloids and MNP. The observed effect is also discussed with respect to potential applications for ordering lysozyme amyloid fibrils in a liquid crystal phase under external magnetic fields.

Note: (c) Elsevier B.V. Post referee full text in progress (embargo 1 year from 12.07.16).

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Contributing Institute(s):

1. EMBL-User (EMBL-User)

Research Program(s):

1. 6G3 - PETRA III (POF3-622) (POF3-622)

Experiment(s):

1. PETRA Beamline P12 (PETRA III)

Appears in the scientific report 2016

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Database coverage:
; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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