Journal Article

PUBDB-2015-01620

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Insight into Bio-metal Interface Formation in vacuo: Interplay of S-layer Protein with Copper and Iron

Makarova, A. A. (Corresponding Author) ; Grachova, E. V. ; Neudachina, V. S. ; Yashina, L. V. ; Blüher, A. ; Molodtsov, S.>Extern*XFEL* ; Mertig, M. ; Ehrlich, H. ; Adamchuk, V. K. ; Laubschat, C. ; Vyalikh, D. V.

2015
Nature Publishing Group London

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Please use a persistent id in citations: doi:10.1038/srep08710

Abstract: The mechanisms of interaction between inorganic matter and biomolecules, as well as properties of resulting hybrids, are receiving growing interest due to the rapidly developing field of bionanotechnology. The majority of potential applications for metal-biohybrid structures require stability of these systems under vacuum conditions, where their chemistry is elusive, and may differ dramatically from the interaction between biomolecules and metal ions in vivo. Here we report for the first time a photoemission and X-ray absorption study of the formation of a hybrid metal-protein system, tracing step-by-step the chemical interactions between the protein and metals (Cu and Fe) in vacuo. Our experiments reveal stabilization of the enol form of peptide bonds as the result of protein-metal interactions for both metals. The resulting complex with copper appears to be rather stable. In contrast, the system with iron decomposes to form inorganic species like oxide, carbide, nitride, and cyanide.

Note: OA

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Contributing Institute(s):

1. European XFEL (Eur.XFEL)

Research Program(s):

1. 6G13 - XFEL (POF3-622) (POF3-622)

Experiment(s):

1. Measurement at external facility

Appears in the scientific report 2015

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Database coverage:
; ; ; ; BIOSIS Previews ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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