TY  - JOUR
AU  - Makarova, Anna A.
AU  - Grachova, Elena V.
AU  - Neudachina, Vera S.
AU  - Yashina, Lada V.
AU  - Blüher, Anja
AU  - Molodtsov, Serguei
AU  - Mertig, Michael
AU  - Ehrlich, Hermann
AU  - Adamchuk, Vera K.
AU  - Laubschat, Clemens
AU  - Vyalikh, Denis V.
TI  - Insight into Bio-metal Interface Formation in vacuo: Interplay of S-layer Protein with Copper and Iron
JO  - Scientific reports
VL  - 5
SN  - 2045-2322
CY  - London
PB  - Nature Publishing Group
M1  - PUBDB-2015-01620
SP  - 8710
PY  - 2015
N1  - OA
AB  - The mechanisms of interaction between inorganic matter and biomolecules, as well as properties of resulting hybrids, are receiving growing interest due to the rapidly developing field of bionanotechnology. The majority of potential applications for metal-biohybrid structures require stability of these systems under vacuum conditions, where their chemistry is elusive, and may differ dramatically from the interaction between biomolecules and metal ions in vivo. Here we report for the first time a photoemission and X-ray absorption study of the formation of a hybrid metal-protein system, tracing step-by-step the chemical interactions between the protein and metals (Cu and Fe) in vacuo. Our experiments reveal stabilization of the enol form of peptide bonds as the result of protein-metal interactions for both metals. The resulting complex with copper appears to be rather stable. In contrast, the system with iron decomposes to form inorganic species like oxide, carbide, nitride, and cyanide.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000350374500001
C6  - pmid:25736576
DO  - DOI:10.1038/srep08710
UR  - https://bib-pubdb1.desy.de/record/208184
ER  -