guest ::
| Home > Publications database > Automated identification and classification of single particle serial femtosecond X-ray diffraction data |
| Home > Publications database > Automated identification and classification of single particle serial femtosecond X-ray diffraction data |
| Journal Article | DESY-2014-02798 |
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
2014
The Optical Society
Washington, DC
This record in other databases: 
Please use a persistent id in citations: doi:10.1364/OE.22.002497
Abstract: The first hard X-ray laser, the Linac Coherent Light Source (LCLS), produces 120 shots per second. Particles injected into the X-ray beam are hit randomly and in unknown orientations by the extremely intense X-ray pulses, where the emtosecond-duration X-ray pulses diffract from the sample before the particle structure is significantly changed eventhough the sample is ultimately destroyed by the deposited X-ray energy. Single particle X-ray diffraction experiments generate data at the FEL repetition rate, resulting in more than 400,000 detector readouts in an hour,the data stream during an experiment contains blank frames mixed with hits on single particles, clusters and ontaminants. The diffraction signal is generally weak and it is superimposed on a low but continually fluctuatingbackground signal, originating from photon noise in the beam line and electronic noise from the detector. Meanwhile, explosion of the sample creates fragments with a characteristic signature. Here, we describe methods based on rapid image analysis combined with ion Time-of-Flight (ToF) spectroscopy of the fragments to achieve an efficient, automated andunsupervised sorting of diffraction data. The studies described here form a basis for the development of real-time frame rejection methods, e.g. for the European XFEL, which is expected to produce 100 million pulses per hour.
; 
; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record
|
The record appears in these collections: |
PDF
