Journal Article

DESY-2014-02479

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Production of Macrocyclic Sesqui- and Diterpenes in Heterologous Microbial Hosts: A Systems Approach to Harness Nature’s Molecular Diversity

Brueck, T. (Corresponding Author) ; Kourist, R. ; Loll, B.Extern*>EMBL*

2014
WILEY-VCH Verlag Weinheim

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Please use a persistent id in citations: doi:10.1002/cctc.201300733

Abstract: Macrocyclic sesqui- (C15) and diterpenes (C20) are a functionally diverse group of natural products with versatile bioactivities encompassing anticancer, antimicrobial and insecticidal agents. Structural complexity prevents economically efficient total synthesis of these higher terpenoids. Heterologous production in recombinant whole-cell biocatalysts is an emerging alternative. Conventional cell systems (i.e., Escherichia coli and Saccharomyces cerevisiae) frequently suffer from low volumetric yields. However, recent combinations of metabolic, enzyme and process engineering in conjunction with systems biology allow significant improvements towards economically viable processes. This Review analyzes research trends in the dynamic fields of terpene-centered microbial cell systems and enzyme engineering. An outlook is given on emerging microbial hosts, which may simplify cellular engineering towards higher product titers.

Note: (c) WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Post referee fulltext in progress.

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Contributing Institute(s):

1. EMBL-User (EMBL-User)

Research Program(s):

1. PETRA Beamline P14 (POF2-54G14) (POF2-54G14)

Experiment(s):

1. PETRA Beamline P14 (PETRA III)

Appears in the scientific report 2014

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Database coverage:
; JCR ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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