Home > Publications database > Production of Macrocyclic Sesqui- and Diterpenes in Heterologous Microbial Hosts: A Systems Approach to Harness Nature’s Molecular Diversity > print

001     168312
005     20250730143924.0
024 7 _ |a 10.1002/cctc.201300733
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037 _ _ |a DESY-2014-02479
041 _ _ |a English
082 _ _ |a 540
100 1 _ |a Brueck, T.
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|e Corresponding Author
245 _ _ |a Production of Macrocyclic Sesqui- and Diterpenes in Heterologous Microbial Hosts: A Systems Approach to Harness Nature’s Molecular Diversity
260 _ _ |a Weinheim
|c 2014
|b WILEY-VCH Verlag
336 7 _ |a Journal Article
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336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
|2 BibTeX
500 _ _ |3 POF3_Assignment on 2016-02-10
500 _ _ |a (c) WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Post referee fulltext in progress.
520 _ _ |a Macrocyclic sesqui- (C15) and diterpenes (C20) are a functionally diverse group of natural products with versatile bioactivities encompassing anticancer, antimicrobial and insecticidal agents. Structural complexity prevents economically efficient total synthesis of these higher terpenoids. Heterologous production in recombinant whole-cell biocatalysts is an emerging alternative. Conventional cell systems (i.e., Escherichia coli and Saccharomyces cerevisiae) frequently suffer from low volumetric yields. However, recent combinations of metabolic, enzyme and process engineering in conjunction with systems biology allow significant improvements towards economically viable processes. This Review analyzes research trends in the dynamic fields of terpene-centered microbial cell systems and enzyme engineering. An outlook is given on emerging microbial hosts, which may simplify cellular engineering towards higher product titers.
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700 1 _ |a Kourist, R.
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700 1 _ |a Loll, Bernhard
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773 _ _ |a 10.1002/cctc.201300733
|0 PERI:(DE-600)2501161-3
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|p 1142–1165
|t ChemCatChem
|v 6
|y 2014
|x 1867-3880
909 C O |o oai:bib-pubdb1.desy.de:168312
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910 1 _ |a Europäisches Laboratorium für Molekularbiologie
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910 1 _ |a Externes Institut
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913 2 _ |a DE-HGF
|b Forschungsbereich Materie
|l Von Materie zu Materialien und Leben
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|v Facility topic: Research on Matter with Brilliant Light Sources
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913 1 _ |b Struktur der Materie
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914 1 _ |y 2014
915 _ _ |a Peer review unknown
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